Graduated from Universidad de La Habana, Cuba.
Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC). INBIAS, CONICET-UNRC, Río Cuarto, 5800 Córdoba, Argentina.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102585. doi: 10.1016/j.pdpdt.2021.102585. Epub 2021 Oct 21.
Glioblastoma is one of the most malignant types of brain cancer. Evidence suggests that within gliomas there is a small subpopulation of cells with the capacity for self-renewal, called glioma stem cells. These cells could be responsible for tumorigenesis, chemo and radioresistance, and finally for the recurrence of the tumor. Fluorescence-guided resection have improved the results of treatment against this disease, prolonging the survival of patients by a few months. Also, clinical trials have reported potential improvements in the therapeutic response after photodynamic therapy. Thus far, there are few published works that show the response of glioblastoma stem-like cells to photodynamic therapy. Here, we present a brief review exclusively commenting on the therapeutic approaches to eliminate glioblastoma stem cells and on the research publications about this topic of glioblastoma stem cells in relation to photodynamic therapy. It is our hope that this review will be useful to provide an overview about what is known to date on the topic and to promote the generation of new ideas for the eradication of glioblastoma stem cells by photodynamic treatment.
胶质母细胞瘤是最恶性的脑癌类型之一。有证据表明，在神经胶质瘤中存在一小部分具有自我更新能力的细胞，称为神经胶质瘤干细胞。这些细胞可能负责肿瘤发生、化疗和放疗耐药，最终导致肿瘤复发。荧光引导切除已改善了针对这种疾病的治疗结果，使患者的生存时间延长了几个月。此外，临床试验报告了光动力疗法后治疗反应的潜在改善。到目前为止，很少有发表的文献显示神经胶质瘤干细胞样细胞对光动力疗法的反应。在这里，我们仅简要回顾了消除神经胶质瘤干细胞的治疗方法，并回顾了与光动力疗法相关的关于神经胶质瘤干细胞的研究文献。我们希望本综述将有助于提供关于该主题的最新知识概述，并为通过光动力治疗根除神经胶质瘤干细胞提供新的思路。
