Nguyen Michelle M, Perlman George, Kim Nakyung, Wu Che-Yuan, Daher Valerie, Zhou Angela, Mathers Emily H, Anita Natasha Z, Lanctôt Krista L, Herrmann Nathan, Pakosh Maureen, Swardfager Walter
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto M4N 3M5, Canada; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto M5S 1A8, Canada; Sleep and Cardiopulmonary Program, University Health Network - Toronto Rehabilitation Institute, 347 Rumsey Road, Toronto M4G 2V6, Canada.
Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto M5S 1A8, Canada.
Psychoneuroendocrinology. 2021 Oct 13;134:105448. doi: 10.1016/j.psyneuen.2021.105448.
The prevalence of depression is higher among people with type 2 diabetes (T2DM). Individually, both conditions are associated with systemic inflammation. This study aimed to summarize the clinical data comparing peripheral inflammatory markers in blood between people with T2DM, with and without comorbid depression. From 2187 records, we identified 20 original peer-reviewed articles from which blood inflammatory marker concentrations could be combined and compared between people with T2DM and comorbid depression (D) vs. no depression (ND) as standardized mean differences (SMD) in random effects meta-analysis. Concentrations of C-reactive protein (CRP; N/N = 1742/15244, SMD = 0.31 95% confidence interval [0.16, 0.45], Z = 4.03, p < 0.01; I = 84.0%) and interleukin-6 (IL-6; N/N = 677/4349, SMD = 0.17 [0.04, 0.30], Z = 2.58, p = 0.01; I = 48.1%), were higher, and concentrations of brain derived neurotrophic factor (BDNF; N/N = 358/1512, SMD = -0.37 95% confidence interval [-0.64,-0.10], Z = -2.68, p = 0.01; I = 61.2%) were lower, among those with depression. Depression in T2DM was associated with systemic inflammation and lower peripheral blood BDNF concentrations. Inconsistency between studies suggests the need to explore further population heterogeneity and pathophysiological elements. PROSPERO (CRD42020188509).
2型糖尿病（T2DM）患者中抑郁症的患病率较高。单独来看，这两种疾病都与全身炎症有关。本研究旨在总结临床数据，比较合并或未合并抑郁症的T2DM患者血液中的外周炎症标志物。从2187份记录中，我们识别出20篇经同行评审的原始文章，从中可以合并血液炎症标志物浓度，并在随机效应荟萃分析中比较合并抑郁症（D）与未患抑郁症（ND）的T2DM患者之间的标准化平均差异（SMD）。抑郁症患者中，C反应蛋白（CRP；N/N = 1742/15244，SMD = 0.31，95%置信区间[0.16, 0.45]，Z = 4.03，p < 0.01；I² = 84.0%）和白细胞介素-6（IL-6；N/N = 677/4349，SMD = 0.17 [0.04, 0.30]，Z = 2.58，p = 0.01；I² = 48.1%）的浓度较高，而脑源性神经营养因子（BDNF；N/N = 358/1512，SMD = -0.37，95%置信区间[-0.64, -0.10]，Z = -2.68，p = 0.01；I² = 61.2%）的浓度较低。T2DM患者的抑郁症与全身炎症和外周血BDNF浓度降低有关。研究之间的不一致表明需要进一步探索人群异质性和病理生理因素。国际前瞻性系统评价注册库（PROSPERO）（CRD42020188509）。
