对乙酰氨基酚对人体戊巴比妥羟基化的影响：一种同时测定未衍生化对乙酰氨基酚和巴比妥类药物的气相色谱法。

Effect of paracetamol on amylobarbitone hydroxylation in man: a gas chromatographic method for simultaneous estimation of underivatized paracetamol and barbiturates.

作者信息

Kinsella H C, Smith S, Rogers H J, Toseland P A

出版信息

J Pharm Pharmacol. 1979 Mar;31(3):153-6. doi: 10.1111/j.2042-7158.1979.tb13458.x.

DOI:10.1111/j.2042-7158.1979.tb13458.x

Abstract

A rapid and specific technique for the simultaneous gas chromatographic estimation of underivatized paracetamol and barbiturates using an alkali flame ionization detector is described which is suitable for both forensic and pharmacokinetic investigations. An improved method for estimation of 3-hydroxyamylobarbitone is also detailed. These techniques were used in an investigation of the effects of oral administration of 1 g paracetamol 8 hourly on the formation of 3-hydroxyamylobarbitone from a single oral dose of 200 mg sodium amylobarbitone. No significant changes were found in the plasma concentrations and total body clearance of amylobarbitone nor was there any alteration in the urinary elimination of 3-hydroxyamylobarbitone.

摘要

本文描述了一种使用碱火焰离子化检测器同时气相色谱法测定未衍生化对乙酰氨基酚和巴比妥类药物的快速、特异性技术，该技术适用于法医和药代动力学研究。还详细介绍了一种改进的3-羟基戊巴比妥测定方法。这些技术用于研究每8小时口服1g对乙酰氨基酚对单次口服200mg戊巴比妥钠后3-羟基戊巴比妥形成的影响。戊巴比妥的血浆浓度和全身清除率未发现显著变化，3-羟基戊巴比妥的尿排泄也没有改变。