Department of Ophthalmology, Kusum Dhirajlal Hospital, Vaishnodevi Circle, SG Road, Ahmedabad, 382421, Gujarat, India.
Kusum Dhirajlal Hospital, Vaishnodevi Circle, SG Road, Ahmedabad, 382421, Gujarat, India.
Int J Infect Dis. 2021 Dec;113:282-287. doi: 10.1016/j.ijid.2021.10.032. Epub 2021 Oct 21.
To comparatively evaluate ICU requirement, length of stay, and mortality between single-dose vaccinated and non-vaccinated hospitalized COVID-19 patients.
A retrospective observational study was carried out in a tertiary care hospital in western Indian, from April 1 to June 30, 2021.
Of the 569 patients who fulfilled the eligibility criteria and were enrolled in the study, 137 (24.08%) patients had received a single dose of ChAdOx1 nCoV-19 vaccine, while 432 (75.92%) patients had not received any form of vaccination. The overall length of stay in hospital was similar for both groups; however, a significant difference was seen in length of stay in the ward and in the ICU. Vaccinated patients were admitted to the ward for 6.21 ± 3.204 days, while non-vaccinated patients were admitted for 5.56 ± 4.55 days (p < 0.001). The mean length of ICU stay for the 21 vaccinated patients requiring intensive care was 4.47 ± 2.3 days, while that for the 145 non-vaccinated patients was 6.29 ± 2.19 days (p < 0.001). Mortality was observed in four patients in the vaccinated group and in 95 patients in the non-vaccinated group.
A single dose of ChAdOx1 nCoV-19 vaccine was associated with a significantly lower severity of SARS-CoV-2 infection compared with no vaccination.
比较评估单剂接种和未接种住院 COVID-19 患者的 ICU 需求、住院时间和死亡率。
这是 2021 年 4 月 1 日至 6 月 30 日在印度西部一家三级护理医院进行的回顾性观察性研究。
符合纳入标准并被纳入研究的 569 名患者中，137 名（24.08%）患者接种了一剂 ChAdOx1 nCoV-19 疫苗，而 432 名（75.92%）患者未接种任何形式的疫苗。两组患者的总体住院时间相似；然而，在病房和 ICU 的住院时间上存在显著差异。接种疫苗的患者在病房的住院时间为 6.21 ± 3.204 天，而未接种疫苗的患者为 5.56 ± 4.55 天（p < 0.001）。21 名需要重症监护的接种患者的 ICU 平均住院时间为 4.47 ± 2.3 天，而 145 名未接种疫苗的患者为 6.29 ± 2.19 天（p < 0.001）。接种组有 4 名患者死亡，未接种组有 95 名患者死亡。
与未接种疫苗相比，一剂 ChAdOx1 nCoV-19 疫苗接种与 SARS-CoV-2 感染的严重程度显著降低相关。
