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[严重烧伤治疗的过去、现在与未来]

[Past, present, and future of critical burn treatment].

作者信息

Guo G H, Jiang Z Y

机构信息

Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2021 Oct 20;37(10):905-910. doi: 10.3760/cma.j.cn501120-20210209-00055.

DOI:10.3760/cma.j.cn501120-20210209-00055
PMID:34689459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917299/
Abstract

The fatality rate of patients with critical burns is extremely high, and the clinical treatment is challenging. By reviewing the history on treatment of critically ill burns patients, this article elaborates and analyzes the advanced concepts and technologies at home and abroad about the critical burn treatment in the areas including shock and fluid resuscitation, hypermetabolism and nutrition, inhalation injury and respiratory support, acute kidney injury and continuous renal replacement therapy, wound assessment and management, infection and control, coagulopathy and its prevention and treatment, etc. Furthermore, some thoughts on the future development trend of critical burn treatment are put forward as reference for people in the same field.

摘要

严重烧伤患者的死亡率极高,临床治疗颇具挑战性。通过回顾重症烧伤患者的治疗历程,本文阐述并分析了国内外在严重烧伤治疗领域的先进理念和技术,涵盖休克与液体复苏、高代谢与营养、吸入性损伤与呼吸支持、急性肾损伤与连续性肾脏替代治疗、创面评估与处理、感染与控制、凝血功能障碍及其防治等方面。此外,还对严重烧伤治疗的未来发展趋势提出了一些思考,以供同行参考。

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1
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2
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本文引用的文献

1
[Research advances on assisted analgesic and sedative treatment of burn children].[小儿烧伤辅助镇痛镇静治疗的研究进展]
Zhonghua Shao Shang Za Zhi. 2020 Oct 20;36(10):979-982. doi: 10.3760/cma.j.cn501120-20190731-00327.
2
Does High-Frequency Chest Wall Oscillation Have an Impact on Improving Pulmonary Function in Patients With Smoke Inhalation Injury?高频胸壁振荡对改善烟雾吸入伤患者肺功能的影响
J Burn Care Res. 2021 Mar 4;42(2):300-304. doi: 10.1093/jbcr/iraa147.
3
BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway.骨髓间充质干细胞来源的外泌体通过阻断 HMGB1/NF-κB 通路缓解烟雾吸入性肺损伤。
Life Sci. 2020 Sep 15;257:118042. doi: 10.1016/j.lfs.2020.118042. Epub 2020 Jul 1.
4
Stem cell derived exosomes-based therapy for acute lung injury and acute respiratory distress syndrome: A novel therapeutic strategy.基于干细胞衍生的外泌体的急性肺损伤和急性呼吸窘迫综合征治疗:一种新的治疗策略。
Life Sci. 2020 Aug 1;254:117766. doi: 10.1016/j.lfs.2020.117766. Epub 2020 May 11.
5
[Pediatric inhalation injury].
Zhonghua Shao Shang Za Zhi. 2020 Apr 20;36(4):247-251. doi: 10.3760/cma.j.cn501120-20191002-00393.
6
Current status and future outlook of nano-based systems for burn wound management.用于烧伤创面管理的纳米基系统的现状与未来展望
J Biomed Mater Res B Appl Biomater. 2020 Jul;108(5):1934-1952. doi: 10.1002/jbm.b.34535. Epub 2019 Dec 30.
7
Validity of thermography for measuring burn wound healing potential.热成像技术测量烧伤创面愈合潜力的有效性。
Wound Repair Regen. 2020 May;28(3):347-354. doi: 10.1111/wrr.12786. Epub 2019 Dec 14.
8
Initial management of severe burn injury.严重烧伤的初始处理。
Curr Opin Crit Care. 2019 Dec;25(6):647-652. doi: 10.1097/MCC.0000000000000662.
9
Management and prevention of drug resistant infections in burn patients.烧伤患者耐药感染的管理与预防。
Expert Rev Anti Infect Ther. 2019 Aug;17(8):607-619. doi: 10.1080/14787210.2019.1648208. Epub 2019 Aug 4.
10
Artificial intelligence and machine learning for predicting acute kidney injury in severely burned patients: A proof of concept.人工智能和机器学习在预测严重烧伤患者急性肾损伤中的应用:概念验证。
Burns. 2019 Sep;45(6):1350-1358. doi: 10.1016/j.burns.2019.03.021. Epub 2019 Jun 21.