伊朗急性肾盂肾炎患儿肾实质损伤相关的人口学、临床和实验室因素。
Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis.
机构信息
Children's Hospital Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
出版信息
BMC Infect Dis. 2021 Oct 24;21(1):1096. doi: 10.1186/s12879-021-06798-x.
BACKGROUND
The association between renal parenchyma changes on dimercaptosuccinic acid (DMSA) scans and demographic, clinical, and laboratory markers was assessed in pediatric patients with acute pyelonephritis.
METHODS
A retrospective study of 67 Iranian babies and children aged 1-month to 12-year with APN was conducted between 2012 and 2018. The presence of renal parenchymal involvement (RPI) during APN was determined using technetium-99m DMSA during the first 2 weeks of hospitalization. The association of DMSA results with demographic data, clinical features (hospitalization stay, fever temperature and duration), and laboratory parameters such as pathogen type, and hematological factors (ESR, CRP, BUN, Cr, Hb, and WBC) was evaluated.
RESULTS
92.5% of children with an average age of 43.76 ± 5.2 months were girls. Twenty-four children (35.8%) did not have renal parenchymal injury (RPI), while 26 (38.8%) and 17 (25.4%) patients showed RPI in one and both kidneys, respectively. There was no significant association between RPI and mean ESR, CRP, BUN, and WBC. However, there were significant associations between RPI and higher mean levels of Cr, Hb, and BMI.
CONCLUSIONS
Low BMI and Hb levels and increased Cr levels might be indicative of the presence of RPI in children with APN.
背景
本研究评估了儿童急性肾盂肾炎（APN）患者的肾脏实质变化与人口统计学、临床和实验室标志物之间的关系。
方法
对 2012 年至 2018 年间的 67 名年龄在 1 个月至 12 岁的伊朗婴儿和儿童进行了回顾性研究，这些儿童患有 APN。在住院的前 2 周，使用锝-99m 二巯丁二酸（DMSA）扫描确定 APN 期间是否存在肾实质受累（RPI）。评估 DMSA 结果与人口统计学数据、临床特征（住院时间、发热温度和持续时间）以及实验室参数（病原体类型和血液学因素）之间的关系，这些因素包括 ESR、CRP、BUN、Cr、Hb 和 WBC。
结果
92.5%的患儿为女性，平均年龄为 43.76±5.2 个月。24 名患儿（35.8%）无肾实质损伤（RPI），26 名（38.8%）和 17 名（25.4%）患儿分别有单侧和双侧 RPI。RPI 与平均 ESR、CRP、BUN 和 WBC 之间无显著相关性。然而，RPI 与较高的平均 Cr、Hb 和 BMI 水平之间存在显著相关性。
结论
低 BMI 和 Hb 水平以及 Cr 水平升高可能提示 APN 患儿存在 RPI。
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