阿戈美拉汀用于老年抑郁症女性患者导致急性肝炎：病例系列
Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series.
作者信息
Chang Cheng-Chen, Chen Yen-Jen, Chen Yu-An, Liao Yi-Cheng
机构信息
Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
出版信息
Clin Psychopharmacol Neurosci. 2021 Nov 30;19(4):789-792. doi: 10.9758/cpn.2021.19.4.789.
Abstract
Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.
摘要
尽管阿戈美拉汀可能与肝毒性风险增加有关，但急性肝炎的发病率在临床试验和日常实践中似乎存在差异。阿戈美拉汀导致肝毒性的风险因素是否为年龄或性别尚不清楚。我们报告3例老年女性病例，她们因阿戈美拉汀极有可能导致特异质性药物性肝损伤而发生急性肝炎。从这些病例来看，对服用抗抑郁药的老年女性进行肝功能定期监测将有益处。
相似文献
1
Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series.阿戈美拉汀用于老年抑郁症女性患者导致急性肝炎：病例系列
Clin Psychopharmacol Neurosci. 2021 Nov 30;19(4):789-792. doi: 10.9758/cpn.2021.19.4.789.
2
A systematic review of agomelatine-induced liver injury.阿戈美拉汀所致肝损伤的系统评价。
J Mol Psychiatry. 2015 Apr 21;3(1):4. doi: 10.1186/s40303-015-0011-7. eCollection 2015.
3
Antidepressant-induced liver injury: a review for clinicians.抗抑郁药相关肝损伤：临床医生的综述。
Am J Psychiatry. 2014 Apr;171(4):404-15. doi: 10.1176/appi.ajp.2013.13050709.
4
What combinations of agomelatine with other antidepressants could be successful during the treatment of major depressive disorder or anxiety disorders in clinical practice?在临床实践中，阿戈美拉汀与其他抗抑郁药的哪些联合用药方案在治疗重度抑郁症或焦虑症时可能会取得成功？
Ther Adv Psychopharmacol. 2019 Jul 7;9:2045125319855206. doi: 10.1177/2045125319855206. eCollection 2019.
5
Agomelatine for postpartum depression and breastfeeding.阿戈美拉汀用于产后抑郁症及母乳喂养
Ther Adv Psychopharmacol. 2021 Jun 3;11:20451253211022172. doi: 10.1177/20451253211022172. eCollection 2021.
6
Comparison of paroxetine and agomelatine in depressed type 2 diabetes mellitus patients: a double-blind, randomized, clinical trial.帕罗西汀与阿戈美拉汀治疗2型糖尿病合并抑郁症患者的比较：一项双盲、随机临床试验。
Neuropsychiatr Dis Treat. 2015 May 27;11:1307-11. doi: 10.2147/NDT.S85711. eCollection 2015.
7
Agomelatine for Depression in Schizophrenia: A Case-Series.阿戈美拉汀治疗精神分裂症伴发的抑郁：病例系列
Psychopharmacol Bull. 2012 Feb 15;45(1):35-43.
8
Agomelatine as monotherapy for major depression: an outpatient, open-label study.阿戈美拉汀单药治疗重性抑郁障碍：一项门诊、开放标签研究。
Neuropsychiatr Dis Treat. 2013;9:1595-604. doi: 10.2147/NDT.S49062. Epub 2013 Oct 22.
9
[Hepatic tolerance of atypical antipsychotic drugs].[非典型抗精神病药物的肝脏耐受性]
Encephale. 2002 Nov-Dec;28(6 Pt 1):542-51.
10
A comparative study of the clinical efficacy and safety of agomelatine with escitalopram in major depressive disorder patients: A randomized, parallel-group, phase IV study.阿戈美拉汀与艾司西酞普兰治疗重度抑郁症患者的临床疗效及安全性比较研究：一项随机、平行组、IV期研究。
J Pharmacol Pharmacother. 2015 Oct-Dec;6(4):198-203. doi: 10.4103/0976-500X.171883.
本文引用的文献
1
Agomelatine for the Treatment of Generalized Anxiety Disorder: A Meta-Analysis.阿戈美拉汀治疗广泛性焦虑障碍：一项荟萃分析。
Clin Psychopharmacol Neurosci. 2020 Aug 31;18(3):423-433. doi: 10.9758/cpn.2020.18.3.423.
2
Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries: A Cohort and Nested Case-Control Study Using Automated Health Data Sources.在四个欧洲国家中，阿戈美拉汀和其他抗抑郁药使用者发生急性肝损伤的风险：使用自动化健康数据源的队列和巢式病例对照研究。
CNS Drugs. 2019 Apr;33(4):383-395. doi: 10.1007/s40263-019-00611-9.
3
Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database.抗抑郁药与肝毒性：在法国国家健康保险数据库中注册的 500 万人的队列研究。
CNS Drugs. 2018 Jul;32(7):673-684. doi: 10.1007/s40263-018-0537-1.
4
Pooled Analysis of Four Non-Interventional Studies: Effectiveness and Tolerability of the Antidepressant Agomelatine in Daily Practice.四项非干预性研究的汇总分析：抗抑郁药阿戈美拉汀在日常临床中的有效性和耐受性
Adv Ther. 2017 Apr;34(4):895-914. doi: 10.1007/s12325-017-0485-z. Epub 2017 Feb 18.
5
Agomelatine versus Sertraline: An Observational, Open-labeled and 12 Weeks Follow-up Study on Efficacy and Tolerability.阿戈美拉汀与舍曲林对比：一项关于疗效和耐受性的观察性、开放标签且为期12周的随访研究
Clin Psychopharmacol Neurosci. 2016 Nov 30;14(4):351-356. doi: 10.9758/cpn.2016.14.4.351.
6
Hepatotoxicity associated with agomelatine and other antidepressants: Disproportionality analysis using pooled pharmacovigilance data from the Uppsala Monitoring Centre.阿戈美拉汀及其他抗抑郁药相关的肝毒性：使用乌普萨拉监测中心汇总的药物警戒数据进行的不成比例性分析。
J Clin Pharmacol. 2015 Jul;55(7):768-73. doi: 10.1002/jcph.475. Epub 2015 Mar 9.
7
Pharmacokinetic evaluation of agomelatine for the treatment of generalised anxiety disorder.阿戈美拉汀治疗广泛性焦虑障碍的药代动力学评价。
Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):885-92. doi: 10.1517/17425255.2014.907794. Epub 2014 Apr 9.
8
Antidepressant-induced liver injury: a review for clinicians.抗抑郁药相关肝损伤：临床医生的综述。
Am J Psychiatry. 2014 Apr;171(4):404-15. doi: 10.1176/appi.ajp.2013.13050709.
9
Agomelatine and hepatotoxicity: implications of cumulated data derived from spontaneous reports of adverse drug reactions.阿戈美拉汀与肝毒性：源于药物不良反应自发报告的累积数据所提示的意义。
Pharmacopsychiatry. 2013 Sep;46(6):214-20. doi: 10.1055/s-0033-1353156. Epub 2013 Aug 21.
10
[Agomelatine: fulminant liver failure in a patient with fatty liver].[阿戈美拉汀：一名脂肪肝患者发生暴发性肝衰竭]
Gastroenterol Hepatol. 2014 Feb;37(2):92-4. doi: 10.1016/j.gastrohep.2013.04.008. Epub 2013 Jul 9.
Zotero 插件