Department of Epidemiology and Prevention, National Center for Global Health and Medicine.
Graduate School of Public Health, Teikyo University.
J Epidemiol. 2023 Jun 5;33(6):311-320. doi: 10.2188/jea.JE20210185. Epub 2022 Apr 15.
Metabolic syndrome (MetS) has been associated with various chronic diseases that may lead to long-term sickness absence (LTSA), but there is lacking information on the direct association between MetS and LTSA. The present study aimed to investigate the all-cause and cause-specific associations between MetS and the risk of medically certified LTSA among Japanese workers.
We recruited 67,403 workers (57,276 men and 10,127 women), aged 20-59 years from 13 companies in Japan during their health check-ups in 2011 (11 companies) and 2014 (2 companies), and we followed them for LTSA events (≥30 consecutive days) until March 31, 2020. MetS was defined according to the Joint Interim Statement. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and its 95% confidence intervals (CIs) for LTSA associated with MetS and its components.
During 408,324 person-years of follow-up, 2,915 workers experienced LTSA. The adjusted HR for all-cause LTSA was 1.54 (95% CI, 1.41-1.68) among those with MetS compared to those without MetS. In cause-specific analysis, HRs associated with MetS significantly increased for LTSA due to overall physical disorders (1.76); cardiovascular diseases (3.16); diseases of the musculoskeletal system and connective tissue (2.01); cancers (1.24); obesity-related cancers (1.35); mental, behavioral, and neurodevelopmental disorders (1.28); reaction to severe stress and adjustment disorders (1.46); and external causes (1.46). The number of MetS components were also significantly associated with increased LTSA risk.
MetS was associated with an increase in the risk of LTSA due to various diseases among Japanese workers.
代谢综合征（MetS）与各种可能导致长期病假（LTSA）的慢性疾病有关，但缺乏 MetS 与 LTSA 之间直接关联的信息。本研究旨在调查日本工人中 MetS 与全因和特定原因 LTSA 风险之间的直接关联。
我们招募了 67403 名工人（57276 名男性和 10127 名女性），他们年龄在 20-59 岁之间，来自日本的 13 家公司，在 2011 年（11 家公司）和 2014 年（2 家公司）的健康检查中，我们对他们进行了随访，以确定 LTSA 事件（≥30 天连续），直到 2020 年 3 月 31 日。MetS 根据联合临时声明进行定义。使用 Cox 比例风险回归模型估计与 MetS 及其成分相关的 LTSA 的风险比（HR）及其 95%置信区间（CI）。
在 408324 人年的随访期间，有 2915 名工人经历了 LTSA。与没有 MetS 的工人相比，患有 MetS 的工人全因 LTSA 的调整后 HR 为 1.54（95%CI，1.41-1.68）。在特定原因分析中，与 MetS 相关的 HR 显著增加，原因是整体身体障碍（1.76）；心血管疾病（3.16）；肌肉骨骼系统和结缔组织疾病（2.01）；癌症（1.24）；肥胖相关癌症（1.35）；精神、行为和神经发育障碍（1.28）；严重应激和适应障碍（1.46）；以及外部原因（1.46）。MetS 的成分数量也与 LTSA 风险的增加显著相关。
代谢综合征与日本工人因各种疾病导致的 LTSA 风险增加有关。
