血清素摄取抑制剂西酞普兰可减少乙醇摄入量。

The serotonin uptake inhibitor citalopram attenuates ethanol intake.

作者信息

Naranjo C A, Sellers E M, Sullivan J T, Woodley D V, Kadlec K, Sykora K

出版信息

Clin Pharmacol Ther. 1987 Mar;41(3):266-74. doi: 10.1038/clpt.1987.27.

DOI:10.1038/clpt.1987.27

Abstract

No effective drug for decreasing ethanol intake is available for clinical use. Our previous studies showed that zimeldine decreased ethanol intake in rats and nondepressed alcohol abusers. However, zimeldine was withdrawn from the market because of serious toxicity. We tested citalopram, a selective serotonin uptake inhibitor, in 39 male nondepressed early-stage problem drinkers (aged 19 to 61 years). Subjects were randomly allocated to receive either citalopram, 20 (n = 20) or 40 (n = 19) mg/day orally, or placebo in a double-blind, crossover trial. Citalopram administration and ethanol intake were assessed by self-report and objectively. Citalopram, 20 mg/day, did not show an effect. However, citalopram, 40 mg/day, decreased the number of drinks consumed (F1,17 = 5.27; P less than 0.05) and increased the number of abstinent days (F1,17 = 13.18; P less than 0.005). The effect is probably through modulation of the neurobiologic mechanisms regulating ethanol intake. Our results suggest a new pharmacologic approach to decrease ethanol intake.

摘要

目前尚无用于临床降低乙醇摄入量的有效药物。我们之前的研究表明，齐美利定可降低大鼠和未患抑郁症的酗酒者的乙醇摄入量。然而，由于严重的毒性，齐美利定已退出市场。我们在39名未患抑郁症的早期男性问题饮酒者（年龄在19至61岁之间）中测试了选择性5-羟色胺再摄取抑制剂西酞普兰。在一项双盲交叉试验中，受试者被随机分配口服西酞普兰，20（n = 20）或40（n = 19）mg/天，或安慰剂。通过自我报告和客观方法评估西酞普兰的给药情况和乙醇摄入量。20 mg/天的西酞普兰未显示出效果。然而，40 mg/天的西酞普兰减少了饮酒量（F1,17 = 5.27；P < 0.05）并增加了戒酒天数（F1,17 = 13.18；P < 0.005）。这种作用可能是通过调节调节乙醇摄入的神经生物学机制实现的。我们的结果提示了一种降低乙醇摄入量的新药理学方法。