Study of the cerebrospinal fluid penetrability of ofloxacin.

In patients with different neurological diseases with blood-brain barrier dysfunction subjected to diagnostic CSF-tap, simultaneous determinations of ofloxacin concentrations in serum and in CSF were carried out. The results show that ofloxacin penetrates well into the CSF achieving adequate bactericidal concentrations against most of the common causative pathogens of meningitis.