Fransen L, Avonts D, Piot P
Infection. 1986;14 Suppl 4:S318-20. doi: 10.1007/BF01661307.
42 men and women with a genital chlamydial infection were randomly treated with a single dose of 200 mg doxycycline daily for ten days or with 200 mg ofloxacin twice a day for nine days. Two weeks after starting treatment 40 patients were able to be reassessed. All 12 men and all seven women treated with doxycycline had clinically improved or healed and had negative cultures for Chlamydia trachomatis. Among the patients treated with ofloxacin, all 11 males had improved or healed and C. trachomatis was not reisolated. These data are promising but larger numbers of patients and a longer follow-up are needed in order to confirm the efficacy of ofloxacin for the treatment of genital chlamydial infections.
42名患有生殖器衣原体感染的男性和女性被随机分为两组，一组每天服用单剂量200毫克强力霉素，持续十天；另一组每天服用200毫克氧氟沙星，分两次服用，持续九天。开始治疗两周后，40名患者能够接受重新评估。所有接受强力霉素治疗的12名男性和7名女性临床症状均有改善或已治愈，沙眼衣原体培养结果为阴性。在接受氧氟沙星治疗的患者中，所有11名男性症状均有改善或已治愈，且未再次分离出沙眼衣原体。这些数据很有前景，但需要更多患者和更长时间的随访来证实氧氟沙星治疗生殖器衣原体感染的疗效。
