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Oral 4-demethoxydaunorubicin (idarubicin) in bronchogenic lung cancer; phase II trial.

作者信息

Hochster H S, Green M D, Blum R H, Wernz J C, Speyer J L, Muggia F M

出版信息

Invest New Drugs. 1986;4(3):275-8. doi: 10.1007/BF00179596.

DOI:10.1007/BF00179596
PMID:3469171
Abstract

Eighteen patients with non-small cell lung cancer were entered into a phase II protocol of oral 4-demethoxydaunorubicin. All were evaluable for toxicity and 17 for response. The major toxicity was hematologic with eight patients developing an ECOG grade 3 or 4 toxicity. There were no responses to the treatment.

摘要

相似文献

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引用本文的文献

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Ann Hematol. 1993 Jan;66(1):33-43. doi: 10.1007/BF01737687.
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Good tolerance of weekly oral idarubicin: (4-demethoxydaunorubicin): a phase I study with pharmacology.每周口服伊达比星（4-去甲氧柔红霉素）耐受性良好：一项伴有药理学研究的I期试验。
Cancer Chemother Pharmacol. 1990;26(4):297-300. doi: 10.1007/BF02897234.
3
Idarubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer.

本文引用的文献

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Antileukemic activity of 4-demethoxydaunorubicin in mice.4-去甲氧基柔红霉素在小鼠体内的抗白血病活性。
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伊达比星。对其药效学和药代动力学特性以及在癌症化疗中的治疗潜力的综述。
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Phase II trial of 4-demethoxydaunorubicin in patients with non-small cell lung cancer.4-去甲氧基柔红霉素用于非小细胞肺癌患者的II期试验。
Cancer Treat Rep. 1984 Mar;68(3):563-4.
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4-Demethoxydaunorubicin (Idarubicin) in refractory or relapsed acute leukemias. A pilot study.4-去甲氧柔红霉素（伊达比星）治疗难治性或复发性急性白血病：一项初步研究。
Cancer. 1985 Apr 1;55(7):1452-4. doi: 10.1002/1097-0142(19850401)55:7<1452::aid-cncr2820550705>3.0.co;2-d.
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Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia.4-去甲氧柔红霉素（伊达比星）治疗成年急性白血病患者的I期和II期临床及药理学研究
Cancer Res. 1985 Mar;45(3):1408-12.
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Antitumor activity of 4-demethoxydaunorubicin administered orally.口服4-去甲氧基柔红霉素的抗肿瘤活性。
Cancer Treat Rep. 1977 Aug;61(5):893-4.
8
Comparison of biochemical and biological methods in the evaluation of new anthracycline drugs.新型蒽环类药物评估中生化与生物学方法的比较
Antibiot Chemother (1971). 1978;23:12-20. doi: 10.1159/000401466.