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癌症中的代谢重编程：连接细胞内应激与癌症行为的桥梁。

Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behaviors.

作者信息

Zhou Yi, Sun Huiyan, Xu Ying

机构信息

Cancer Systems Biology Center, The China-Japan Union Hospital, China.

出版信息

Natl Sci Rev. 2020 Aug;7(8):1270-1273. doi: 10.1093/nsr/nwaa082. Epub 2020 Apr 30.

DOI:10.1093/nsr/nwaa082
PMID:34692153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8288940/
Abstract

Extensive changes in cellular metabolisms have been observed in cancer. They are probably induced by the same intracellular stressor, persistent off-balance in intracellular pH across possibly all adult cancers. It is these altered metabolisms that gives rise to a variety of cancerous behaviors such as continuous cell division, metastasis and drug resistance.

摘要

在癌症中已观察到细胞代谢的广泛变化。它们可能是由相同的细胞内应激源引起的，即所有成年癌症细胞内pH值持续失衡。正是这些改变的代谢导致了多种癌症行为，如持续的细胞分裂、转移和耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a868/8288940/32679e86f7cd/nwaa082fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a868/8288940/32679e86f7cd/nwaa082fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a868/8288940/32679e86f7cd/nwaa082fig1.jpg

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本文引用的文献

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3
Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.癌细胞调整信号通路以促进核苷酸的从头合成。
代谢在乳腺癌细胞与肿瘤相关巨噬细胞串扰中的新兴作用。
Int J Biol Sci. 2023 Sep 18;19(15):4915-4930. doi: 10.7150/ijbs.86039. eCollection 2023.
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Co-expression based cancer staging and application.基于共表达的癌症分期和应用。
Sci Rep. 2020 Jun 30;10(1):10624. doi: 10.1038/s41598-020-67476-7.
Cancers (Basel). 2019 May 17;11(5):688. doi: 10.3390/cancers11050688.
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Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name.癌症和正常增殖细胞中的瓦博格效应：同名异曲。
Genomics Proteomics Bioinformatics. 2019 Jun;17(3):273-286. doi: 10.1016/j.gpb.2018.12.006. Epub 2019 May 7.
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Fenton reactions drive nucleotide and ATP syntheses in cancer.芬顿反应驱动癌症中的核苷酸和 ATP 合成。
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