Kalyan Vamsi, Suvvari Tarun K, Kandula Venkata Dinesh Kumar, Shanker Aparajeya, Matiashova Lolita
Medicine and Surgery, Rangaraya Medical College, Kakinada, IND.
Medicine and Surgery, Dr. N.T.R University of Health Sciences, Vijayawada, IND.
Cureus. 2021 Sep 17;13(9):e18061. doi: 10.7759/cureus.18061. eCollection 2021 Sep.
Mal de Meleda (MDM) is a rare sub-type of palmoplantar keratoderma (PPK) disease. The primary symptoms of PPK are scleroatrophy, transient keratoderma, scleroatrophic erythema, pseudoainhum around the digits, and perioral erythema. MDM is a pathology with a difficult clinical course. This case study presents two cases of MDM in siblings born out of second-degree consanguinity. The presenting complaint was the peeling of the palmar skin since birth. Both patients were treated with acitretin orally (dose: 10 mg) for three months and tretinoin (topical) for two months. The prognosis was good after three months of treatment.
梅勒达病（MDM）是掌跖角化病（PPK）的一种罕见亚型。PPK的主要症状包括硬化萎缩、一过性角化病、硬化萎缩性红斑、手指周围假阿洪病以及口周红斑。MDM是一种临床病程复杂的疾病。本病例研究呈现了两例二级近亲结婚所生的患有MDM的兄弟姐妹。主要症状为自出生起手掌皮肤脱皮。两名患者均口服阿维A（剂量：10毫克）三个月，外用维甲酸两个月。治疗三个月后预后良好。
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