Facile synthesis and anticancer evaluation of a new series of tetrahydroquinoline.

Tetrahydroquinoline () is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were used to confirm the structure of synthesized compounds. Then, they were assessed in against three human cancer cell lines. Consequently, four compounds, , , , and , were identified as promising anticancer agents with pyrazolo quinoline derivative () exhibiting the highest potential IC and a strong apoptotic effect on three cell lines.