Department of Neurology, Neurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Department of Cardiovascular Medicine, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Muscle Nerve. 2022 Jan;65(1):120-125. doi: 10.1002/mus.27447. Epub 2021 Nov 3.
INTRODUCTION/AIMS: Previous studies have shown inconsistent data on the relationship between statin use and polyneuropathy (PN). The current systematic review and meta-analyses were conducted to comprehensively investigate the risk of incident PN among statin-users compared with non-users by identifying all available studies and summarizing their results.
A systematic review was conducted from MEDLINE and EMBASE databases from inception to October 31, 2020. We included cohort and case-control studies that compared the risk of incident PN between statin-users and non-users. Point estimates and standard errors from eligible studies were pooled together using the generic inverse variance method.
Of 4968 retrieved articles, 6 studies in non-diabetic populations and 2 studies in diabetic populations fulfilled the inclusion criteria. Two meta-analyses were performed. The pooled analyses did not find a statistically significant association between the use of statins and risk of incident PN with the pooled odds ratio of 1.24 (95% confidence interval [CI], 0.88-1.76; I 74%) and 0.82 (95% CI, 0.56-1.21; I 80%) in non-diabetic and diabetic groups respectively.
No significant association between the use of statins and the risk of PN was observed in this systematic review and these two meta-analyses. However, there was a high degree of heterogeneity of the meta-analyses.
简介/目的：先前的研究表明，他汀类药物使用与多发性神经病（PN）之间的关系数据不一致。本系统评价和荟萃分析旨在通过确定所有可用的研究并总结其结果，全面调查与非使用者相比，他汀类药物使用者发生 PN 的风险。
从 MEDLINE 和 EMBASE 数据库进行了系统检索，检索时间从建库至 2020 年 10 月 31 日。我们纳入了比较他汀类药物使用者和非使用者发生 PN 风险的队列研究和病例对照研究。使用通用倒数方差法汇总合格研究的点估计值和标准误差。
在检索到的 4968 篇文章中，有 6 项非糖尿病人群的研究和 2 项糖尿病人群的研究符合纳入标准。进行了两项荟萃分析。汇总分析未发现他汀类药物使用与 PN 发生风险之间存在统计学显著关联，汇总比值比分别为 1.24（95%置信区间 [CI]，0.88-1.76；I 74%）和 0.82（95% CI，0.56-1.21；I 80%），分别在非糖尿病组和糖尿病组。
本系统评价和这两项荟萃分析均未观察到他汀类药物使用与 PN 风险之间存在显著关联。然而，荟萃分析存在高度异质性。
