Costlow M E, Pui C H
J Steroid Biochem. 1987 Jan;26(1):15-8. doi: 10.1016/0022-4731(87)90024-0.
Nuclear translocation of glucocorticoid receptors (GR) was measured in lymphoblasts from 45 children with acute lymphoblastic leukemia (ALL). The percent of total GR translocated to the nucleus ranged from 0 to 100% (mean, 59%) and was independent of the total GR level. Neither the extent of GR nuclear translocation nor the absolute amount of GR translocated at 4 or 25 degrees C correlated with glucocorticoid response in 13 patients with single-agent glucocorticoid trial. These results indicate that defects in nuclear translocation of GR are not a common cause for steroid resistance in childhood ALL.
对45例急性淋巴细胞白血病（ALL）患儿的淋巴母细胞进行糖皮质激素受体（GR）核转位检测。转位至细胞核的GR占总GR的百分比范围为0至100%（平均59%），且与总GR水平无关。在13例接受单药糖皮质激素试验的患者中，无论是4℃还是25℃时GR核转位的程度，还是转位的GR绝对量，均与糖皮质激素反应无关。这些结果表明，GR核转位缺陷并非儿童ALL中类固醇耐药的常见原因。
