Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Department of Medical Oncology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Climacteric. 2022 Jun;25(3):228-234. doi: 10.1080/13697137.2021.1990258. Epub 2021 Oct 25.
Genitourinary syndrome of menopause (GSM) may arise from the hypoestrogenism caused by ovarian function destruction following gynecological cancer treatments. GSM may also be present in menopausal women and its symptoms might be exacerbated by cancer treatments. Historically, patients with hormone-dependent gynecological cancer and physicians have been less comfortable using vaginal estrogen due to fear of recurrence. CO vaginal laser therapies have demonstrated efficacy as a non-hormonal alternative for GSM treatment in healthy menopausal patients. The objective of this study was to evaluate the data on the effect of a CO vaginal laser for the management of GSM in gynecological cancer patients. Databases searched included MEDLINE, Embase, PubMed, Cochrane and Google Scholar. Selected studies assessed use of a CO vaginal laser in gynecological cancer patients with GSM. A total of 269 studies were retrieved. Four studies met the inclusion criteria. Each study followed a different type of CO vaginal laser protocol for the management of GSM in gynecological cancer patients. There are no randomized controlled trials that assess the use of a CO vaginal laser in gynecologic cancer patients. The number of published gynecological cancer patients treated with a CO laser for the management of GSM is extremely limited ( < 100). There is a lack of literature on the impact and safety of vaginal CO laser use to manage GSM in gynecologic cancer patients.
绝经后生殖泌尿系统综合征（GSM）可能源于妇科癌症治疗后卵巢功能破坏导致的雌激素水平降低。GSM 也可能发生在绝经后妇女中，并且其症状可能会因癌症治疗而加重。历史上，由于担心复发，激素依赖性妇科癌症患者和医生对使用阴道雌激素不太放心。CO 阴道激光治疗已被证明是一种治疗健康绝经后患者 GSM 的非激素替代疗法。本研究的目的是评估 CO 阴道激光治疗妇科癌症患者 GSM 的效果数据。检索的数据库包括 MEDLINE、Embase、PubMed、Cochrane 和 Google Scholar。选择的研究评估了 CO 阴道激光在 GSM 妇科癌症患者中的应用。共检索到 269 项研究。四项研究符合纳入标准。每项研究都遵循不同类型的 CO 阴道激光方案来管理 GSM 妇科癌症患者。没有评估 CO 阴道激光在妇科癌症患者中的使用的随机对照试验。用 CO 激光治疗 GSM 的妇科癌症患者的已发表病例数量非常有限（<100 例）。关于阴道 CO 激光用于管理妇科癌症患者 GSM 的影响和安全性的文献很少。
