Takata T, Urakawa T, Saitoh Y
Nihon Geka Gakkai Zasshi. 1987 Jan;88(1):49-57.
Gastric wall blood flow, gastric mucosal noradrenalin (NA), gastric mucosal prostaglandin E2 (PGE2) and gastric mucosal energy metabolism were studied after partial hepatectomy in thioacetamide (TAA) --induced cirrhotic rats and these were also tested by loading water immersion restraint on the 3rd day after partial hepatectomy. Furthermore, the preventive effects of PGE2 on ulcers were also examined. Liver cirrhosis rats were prepared with an abdominal administration of TAA three times a week for 10 weeks, after which 70% partial hepatectomies were performed. The results of these tests showed that the gastric mucosa after partial hepatectomy in liver cirrhosis rats had significantly lower gastric wall blood flow, gastric mucosal NA and gastric mucosal energy and reduced gastric mucosal PGE2. The water immersion restraint stress loaded on the 3rd day to these rats after partial hepatectomy caused a noticeable and an earlier reduction in gastric wall blood flow and gastric mucosal PGE2 than to the normal group, and the ulcer index was high. PGE2 administration also appeared to be effective for the prevention of development of acute ulcers after partial hepatectomy in liver cirrhosis rats.
研究了硫代乙酰胺（TAA）诱导的肝硬化大鼠部分肝切除术后的胃壁血流量、胃黏膜去甲肾上腺素（NA）、胃黏膜前列腺素E2（PGE2）和胃黏膜能量代谢，并在部分肝切除术后第3天通过水浸束缚负荷试验对上述指标进行了检测。此外，还研究了PGE2对溃疡的预防作用。通过每周3次腹腔注射TAA，持续10周制备肝硬化大鼠模型，然后进行70%部分肝切除术。这些试验结果表明，肝硬化大鼠部分肝切除术后胃黏膜的胃壁血流量、胃黏膜NA和胃黏膜能量显著降低，胃黏膜PGE2减少。部分肝切除术后第3天对这些大鼠施加水浸束缚应激，导致胃壁血流量和胃黏膜PGE2比正常组出现更明显、更早的降低，且溃疡指数较高。给予PGE2似乎也对预防肝硬化大鼠部分肝切除术后急性溃疡的发生有效。
