Matsui S, Urakawa T, Saitoh Y
Nihon Geka Gakkai Zasshi. 1986 Oct;87(10):1303-12.
Stress ulcer is a common phenomenon after hepatectomy for cirrhotic liver. We examined experimentally the influence of cimetidine and 16,16-dm PGE2 dosaged as counter-measures against stress ulcer on liver regeneration after partial hepatectomy for cirrhotic liver. Using cimetidine and 16,16-dm PGE2, there was a noticeable suppression of the onset of water immersion stress ulcer, and both a decline in the blood flow in the wall of the stomach and a drop in PH in the stomach were inhibited after partial hepatectomy for cirrhotic liver. The group given 16,16-dm PGE2 after partial hepatectomy had a higher rate of DNA synthesis as compared with the group which had only partial hepatectomy. No difference was seen between the group given cimetidine and the only partial hepatectomy groups. The group given indomethacin before partial hepatectomy for cirrhotic liver had a noticeable decrease in mitotic index 30 hours after partial hepatectomy. However, the group given both indomethacin and 16,16-dm pGE2, showed some recovery of the mitotic index.
应激性溃疡是肝硬化肝脏肝切除术后的常见现象。我们通过实验研究了西咪替丁和16,16-二甲基前列腺素E2（16,16-dm PGE2）作为预防应激性溃疡的措施对肝硬化肝脏部分肝切除术后肝脏再生的影响。使用西咪替丁和16,16-dm PGE2后，水浸应激性溃疡的发生得到了显著抑制，肝硬化肝脏部分肝切除术后胃壁血流量的下降和胃内pH值的降低均受到抑制。部分肝切除术后给予16,16-dm PGE2的组与仅进行部分肝切除的组相比，DNA合成率更高。给予西咪替丁的组与仅进行部分肝切除的组之间未见差异。在肝硬化肝脏部分肝切除术前给予吲哚美辛的组在部分肝切除术后30小时有丝分裂指数明显下降。然而，给予吲哚美辛和16,16-dm PGE2的组有丝分裂指数有所恢复。
