鲁帕他定治疗与动脉粥样硬化恶化及T淋巴细胞募集改变有关。 - Suppr

Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment.

作者信息

Busnelli Marco, Manzini Stefano, Colombo Alice, Bonacina Fabrizia, Norata Giuseppe D, Franchi Elsa, Castiglioni Silvia, Andronis Christos, Lekka Eftychia, Scanziani Eugenio, Chiesa Giulia

机构信息

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.

Biovista, Athens, Greece.

出版信息

Thromb Haemost. 2022 May;122(5):853-856. doi: 10.1055/a-1678-4031. Epub 2022 Jan 16.

DOI:10.1055/a-1678-4031

PMID:34695872

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9197591/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/444e/9197591/4a0cf9230b25/10-1055-a-1678-4031-i210126-1.jpg

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Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment.鲁帕他定治疗与动脉粥样硬化恶化及T淋巴细胞募集改变有关。

Thromb Haemost. 2022 May;122(5):853-856. doi: 10.1055/a-1678-4031. Epub 2022 Jan 16.

Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study.卢帕他定治疗慢性特发性荨麻疹：一项双盲、随机、安慰剂对照的多中心研究。

Allergy. 2007 May;62(5):539-46. doi: 10.1111/j.1398-9995.2007.01330.x.

Once-daily rupatadine improves the symptoms of chronic idiopathic urticaria: a randomised, double-blind, placebo-controlled study.每日一次服用卢帕他定可改善慢性特发性荨麻疹症状：一项随机、双盲、安慰剂对照研究。

Eur J Dermatol. 2007 May-Jun;17(3):223-8. doi: 10.1684/ejd.2007.0153. Epub 2007 May 4.

Rupatadine oral solution in children with persistent allergic rhinitis: A randomized, double-blind, placebo-controlled study.鲁帕他定口服溶液治疗持续性变应性鼻炎患儿的随机、双盲、安慰剂对照研究。

Pediatr Allergy Immunol. 2013 Mar;24(2):144-50. doi: 10.1111/pai.12036. Epub 2013 Feb 6.

Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study.在接受芦帕他定治疗的变应性鼻炎患者中，过敏原诱导后鼻腔体积减少：一项随机、交叉、双盲、安慰剂对照研究。

J Investig Allergol Clin Immunol. 2009;19(6):488-93.

Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: A double-blind, randomized, multicenter, placebo-controlled clinical trial.芦帕他定治疗日本季节性变应性鼻炎患者的疗效和安全性：一项双盲、随机、多中心、安慰剂对照临床试验。

Allergol Int. 2019 Apr;68(2):207-215. doi: 10.1016/j.alit.2018.08.011. Epub 2018 Oct 31.

Rupatadine does not potentiate the CNS depressant effects of lorazepam: randomized, double-blind, crossover, repeated dose, placebo-controlled study.芦曲班定不会增强劳拉西泮的中枢神经抑制作用：一项随机、双盲、交叉、重复剂量、安慰剂对照研究。

Br J Clin Pharmacol. 2010 Jun;69(6):663-74. doi: 10.1111/j.1365-2125.2010.03648.x.

Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study.10毫克卢帕他定与10毫克西替利嗪治疗季节性变应性鼻炎：一项随机、双盲平行研究

J Investig Allergol Clin Immunol. 2005;15(1):22-9.

Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria.20毫克和40毫克的卢帕他定对减轻慢性寒冷性荨麻疹症状有效。

Acta Derm Venereol. 2016 Jan;96(1):56-9. doi: 10.2340/00015555-2150.

Lack of effects between rupatadine 10 mg and placebo on actual driving performance of healthy volunteers.10毫克卢帕他定与安慰剂对健康志愿者实际驾驶性能无影响。

Hum Psychopharmacol. 2007 Jul;22(5):289-97. doi: 10.1002/hup.856.

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Aortic Gene Expression Profiles Show How ApoA-I Levels Modulate Inflammation, Lysosomal Activity, and Sphingolipid Metabolism in Murine Atherosclerosis.主动脉基因表达谱显示载脂蛋白 A-I 水平如何调节小鼠动脉粥样硬化中的炎症、溶酶体活性和鞘脂代谢。

Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):651-667. doi: 10.1161/ATVBAHA.120.315669. Epub 2020 Dec 17.

T cell subsets and functions in atherosclerosis.T 细胞亚群及其在动脉粥样硬化中的功能。

Nat Rev Cardiol. 2020 Jul;17(7):387-401. doi: 10.1038/s41569-020-0352-5. Epub 2020 Mar 16.

Fenretinide treatment accelerates atherosclerosis development in apoE-deficient mice in spite of beneficial metabolic effects.芬维 A 酯治疗尽管有有益的代谢作用，但会加速载脂蛋白 E 缺陷小鼠的动脉粥样硬化发展。

Br J Pharmacol. 2020 Jan;177(2):328-345. doi: 10.1111/bph.14869. Epub 2019 Nov 14.

Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications.变应性鼻炎中的血小板活化因子（PAF）：临床及治疗意义

J Clin Med. 2019 Aug 29;8(9):1338. doi: 10.3390/jcm8091338.

Immunity and Inflammation in Atherosclerosis.动脉粥样硬化中的免疫与炎症。

Circ Res. 2019 Jan 18;124(2):315-327. doi: 10.1161/CIRCRESAHA.118.313591.

Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids.托吡酯可保护载脂蛋白 E 缺乏小鼠免受肾脏损伤，而不影响血浆脂质。

Pharmacol Res. 2019 Mar;141:189-200. doi: 10.1016/j.phrs.2018.12.022. Epub 2018 Dec 26.

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets.组胺和组胺受体在肥大细胞介导的过敏和炎症中的作用：寻找新的治疗靶点。

Front Immunol. 2018 Aug 13;9:1873. doi: 10.3389/fimmu.2018.01873. eCollection 2018.

Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE mice.肝特异性敲除 Plpp3 基因改变了载脂蛋白 E 小鼠的血浆脂质组成并加重动脉粥样硬化。

Sci Rep. 2017 Mar 14;7:44503. doi: 10.1038/srep44503.

Mast Cell: A Multi-Functional Master Cell.肥大细胞：一种多功能的主导细胞。

Front Immunol. 2016 Jan 6;6:620. doi: 10.3389/fimmu.2015.00620. eCollection 2015.

Update on rupatadine in the management of allergic disorders.芦帕他定在过敏疾病治疗中的最新进展。

Allergy. 2015 Jan;70 Suppl 100:1-24. doi: 10.1111/all.12531.

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Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment.

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