State Key Laboratory of Precision Measuring Technology and Instruments, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
Sensors (Basel). 2021 Oct 13;21(20):6800. doi: 10.3390/s21206800.
A microfluidic film bulk acoustic wave resonator gas sensor (mFBAR) adapted specifically as an in-line detector in gas chromatography was described. This miniaturized vapor sensor was a non-destructive detector with very low dead volume (0.02 μL). It was prepared by enclosing the resonator in a microfluidic channel on a chip with dimensions of only 15 mm × 15 mm × 1 mm. The device with polymer coating showed satisfactory performance in the detection of organophosphorus compound, demonstrating a very low detection limit (a dozen parts per billion) with relatively short response time (about fifteen seconds) toward the simulant of chemical warfare agent, dimethyl methylphosphonate. The in-line detection of the mFBAR sensor with FID was constructed and employed to directly measure the concentration profile on the solid surface by the mFBAR with the controlled concentration profile in the mobile phase at the same time. The difference of peak-maximum position between mobile phase and solid phase could be a convenient indicator to measure mass transfer rate. With the response of the mFBAR and FID obtained in one injection, an injection mass-independent parameter can be calculated and used to identify the analyte of interest.
描述了一种专门用作气相色谱在线检测器的微流控薄膜体声波谐振器气体传感器（mFBAR）。这种微型蒸汽传感器是一种非破坏性检测器，死体积非常小（0.02 μL）。它是通过将谐振器封装在芯片上的微流道中制成的，芯片尺寸仅为 15mm×15mm×1mm。具有聚合物涂层的器件在检测有机磷化合物方面表现出令人满意的性能，对化学战剂模拟物二甲甲基膦酸酯的检测限非常低（十亿分之几），响应时间相对较短（约十五秒）。通过同时控制流动相中的浓度分布，构建了 mFBAR 与 FID 的在线检测，并利用其直接测量固体表面上的浓度分布。流动相和固体相之间的峰最大值位置的差异可以作为一个方便的指标来测量质量传递速率。通过在一次进样中获得 mFBAR 和 FID 的响应，可以计算出一个与进样量无关的参数，并用于识别感兴趣的分析物。
