[在接受锌-二乙三胺五乙酸和钙-二乙三胺五乙酸长期治疗的大鼠中肌肉注射大量239钚后的行为和生物学作用]
[Behavior and biological action of large amounts of 239Pu following intramuscular administration in rats undergoing long-term therapy with Zn- and Ca-DTPA].
作者信息
Siniakov E G, Bazhin A G, Liubchanskiĭ E R, Nifatov A P
出版信息
Radiobiologiia. 1987 Jan-Feb;27(1):129-30.
PMID:3469686
Abstract
The authors submit the results of the studies of the influence of large amounts of 239Pu, administered to rats via stab wounds, and subsequent treatment there of with clinical doses of Zn- and Ca-DTPA for two months. It is shown that the absorbed doses considerably decrease and the average life of treated rats increases; the incidence of malignant tumors does not change after the treatment with Ca-DTPA.
摘要
作者提交了关于经刺伤给大鼠注射大量239Pu以及随后用临床剂量的锌-二乙三胺五乙酸（Zn-DTPA）和钙-二乙三胺五乙酸（Ca-DTPA）对其进行两个月治疗的影响的研究结果。结果表明，吸收剂量大幅降低，接受治疗的大鼠平均寿命延长；用Ca-DTPA治疗后恶性肿瘤的发生率没有变化。
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