Department of Urology, Teikyo University Chiba Medical Center, Chiba, Japan
Department of Urology, Teikyo University Chiba Medical Center, Chiba, Japan.
In Vivo. 2021 Nov-Dec;35(6):3489-3493. doi: 10.21873/invivo.12650.
BACKGROUND/AIM: We investigated the changes in and characteristics of renal function in Japanese patients with high-risk prostate cancer (PCa) who underwent radiotherapy and long-term androgen deprivation therapy (ADT), including those seen after the ADT was discontinued.
Among 60 patients who were pathologically diagnosed with PCa and received ADT for 24 months and radiotherapy, 36 patients who underwent treatment for stage B or C PCa were eligible. We assessed renal function using the estimated glomerular filtration rate (eGFR) and investigated the rate of change in the eGFR (ΔeGFR) during and after ADT. Univariate and multivariate logistic analyses were carried out to identify clinical factors that were significantly associated with renal dysfunction at 36 months.
The incidence of renal dysfunction at 36 months was 75% (27/36). Multivariate analysis showed that the presence/absence of HF was an independent predictor of renal dysfunction at 36 months.
Renal function tended to recover after ADT was received for 24 months and subsequently discontinued. The presence/absence of HF represents new and meaningful information for patients receiving ADT, and high-risk PCa patients prior to ADT.
背景/目的：我们研究了接受放疗和长期雄激素剥夺治疗（ADT）的高危前列腺癌（PCa）日本患者肾功能的变化和特征，包括 ADT 停药后的变化和特征。
在 60 名经病理诊断为 PCa 并接受 ADT 治疗 24 个月和放疗的患者中，有 36 名接受了 B 期或 C 期 PCa 治疗的患者符合条件。我们使用估算肾小球滤过率（eGFR）评估肾功能，并研究 ADT 期间和之后 eGFR 的变化率（ΔeGFR）。进行单因素和多因素逻辑分析，以确定与 36 个月时肾功能障碍显著相关的临床因素。
36 个月时肾功能障碍的发生率为 75%（27/36）。多因素分析表明，HF 的存在/不存在是 36 个月时肾功能障碍的独立预测因素。
ADT 治疗 24 个月并随后停药后，肾功能趋于恢复。HF 的存在/不存在为接受 ADT 的患者提供了新的有意义的信息，也为 ADT 前的高危 PCa 患者提供了新的有意义的信息。
