急性肝炎肝脏血流动力学改变：应用 CT 灌注的定量评估。
Hemodynamic Alteration in the Liver in Acute Hepatitis: A Quantitative Evaluation Using Computed Tomographic Perfusion.
机构信息
Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan;
Department of Advanced Imaging and Interventional Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3537-3545. doi: 10.21873/invivo.12656.
BACKGROUND/AIM: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging.
PATIENTS AND METHODS
For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors.
RESULTS
The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=-0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02).
CONCLUSION
The PI of the right liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure.
背景/目的：我们旨在使用计算机断层灌注成像阐明急性肝炎（AH）患者肝脏的血流动力学变化。
患者与方法
我们比较了 14 例 AH 患者和 9 例无疾病（ND 组）患者的右肝和左肝叶的平均动脉血流量（AF）、门静脉血流量（PF）和灌注指数（%）[PI=AF/（AF+PF）×100]，并探讨了它们与临床因素的关系。
结果
AH 组右叶的平均 PI（30.5±10.0%）明显高于 ND 组（20.8±9.7%）（p=0.031）。对于 AH 和 ND 两组的所有患者，右叶 PI 随着凝血酶原时间的降低而增加（R=-0.56，p=0.006），随着凝血酶原时间国际标准化比值的增加而增加（R=0.48，p=0.02）。
结论
右肝叶的 PI 在 AH 中可能会增加，并且可能是肝衰竭严重程度的预测参数。
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