Hunt R H, Howden C W, Jones D B, Burget D W, Kerr G D
Scand J Gastroenterol Suppl. 1986;125:22-31. doi: 10.3109/00365528609093814.
Suppression of gastric acid forms the basis of treatment of duodenal and gastric ulcer, but the precise relationship between suppression of acidity and healing rates has not been defined. We examined the results of controlled trials and clinical pharmacological studies of 24-h intragastric acidity involving antisecretory agents. Data on 24-h and nocturnal hydrogen ion activity and nocturnal acid output were obtained, and the healing rates in duodenal ulcer were calculated. Duodenal ulcer healing rates after 4 weeks showed a significant correlation with suppression of 24-hour hydrogen ion activity (r = 0.63; P less than 0.05), and a highly significant correlation between healing and the suppression of nocturnal hydrogen ion activity (r = 0.93; P less than 0.0001). Nocturnal acid output was not significantly correlated. For gastric ulcer, no such association was seen for suppression of either 24-hour or nocturnal hydrogen ion activity. Duodenal ulcer is regarded as an acid-related disorder, but in gastric ulcer other factors may be more important in pathogenesis and treatment.
胃酸抑制是十二指肠溃疡和胃溃疡治疗的基础，但胃酸抑制与愈合率之间的确切关系尚未明确。我们研究了涉及抗分泌药物的24小时胃内酸度的对照试验和临床药理学研究结果。获得了24小时和夜间氢离子活性以及夜间酸分泌量的数据，并计算了十二指肠溃疡的愈合率。4周后十二指肠溃疡的愈合率与24小时氢离子活性的抑制呈显著相关（r = 0.63；P < 0.05），与夜间氢离子活性的抑制呈高度显著相关（r = 0.93；P < 0.0001）。夜间酸分泌量无显著相关性。对于胃溃疡，无论是24小时还是夜间氢离子活性的抑制均未观察到这种关联。十二指肠溃疡被视为一种与酸相关的疾病，但在胃溃疡中，其他因素在发病机制和治疗中可能更为重要。
