Howden C W, Jones D B, Burget D W, Hunt R H
Gut. 1986 Sep;27(9):1058-61. doi: 10.1136/gut.27.9.1058.
Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. The aim was to investigate the relationship between antisecretory effect in the two populations. There was a significant correlation between effect in patients and normal subjects for suppression of 24 hour intragastric acidity (r = 0.732; p = 0.0068), nocturnal intragastric acidity (r = 0.861; p = 0.0033) and nocturnal acid output (r = 0.964; p = 0.0069). The regression lines for 24 hour and nocturnal acidity were very similar. The expected antisecretory effect of a particular dosage regimen in patients with duodenal ulcer can be predicted mathematically from data derived from studies in normal volunteers.
回顾了30项已发表的关于胃抗分泌药物在正常志愿者和十二指肠溃疡患者中临床药理学的研究。目的是研究这两个人群中抗分泌作用之间的关系。在抑制24小时胃内酸度（r = 0.732；p = 0.0068）、夜间胃内酸度（r = 0.861；p = 0.0033）和夜间酸分泌量（r = 0.964；p = 0.0069）方面，患者和正常受试者的作用之间存在显著相关性。24小时和夜间酸度的回归线非常相似。十二指肠溃疡患者特定给药方案的预期抗分泌作用可以根据正常志愿者研究的数据通过数学方法预测。
