Li Chengke, Song Weihai, Lei Yanwen, Peng Songgen, Chu Weiying, Deng Guochao
Department of Orthopedics, Shunde Hospital affiliated to Jinan University (Foshan Shunde Second People's Hospital, Foshan Shunde Feng Yaojing Memorial Hospital), Shunde District, Foshan, Guangdong, China.
Department of Orthopedics, Municipal Hospital Affiliated to Taizhou University, Taizhou, Zhejiang, China.
Evid Based Complement Alternat Med. 2021 Oct 16;2021:1202826. doi: 10.1155/2021/1202826. eCollection 2021.
Patients with skin and soft tissue defects are very common. Mild trauma often causes mild skin damage, while severe injuries are often accompanied by bone and tendon exposure, which brings great pain to patients. For the defect of skin and soft tissue, the traditional treatment methods are mostly medium or full-thickness skin or skin flap transplantation. These methods are effective in wound repair, but there are still many problems. In recent years, with the improvement of tissue engineering technology, the use of artificial skin to repair various skin wounds is gradually becoming clinical, and the key technology of skin tissue engineering lies in the development of dermal substitutes. The appearance of artificial dermis not only solves the shortage of autologous skin source but also makes the operation simple and easy. The purpose of this study was to investigate the clinical effect of artificial dermis combined with autologous skin grafts in repairing hand and foot skin and soft tissue defects with bone exposure. The results show that the use of artificial dermis combined with autogenous blade thick skin to treat patients with hand and foot soft tissue injury with bone exposure has a good clinical effect, and the skin is alive and has fewer complications, which is worthy of promotion.
皮肤和软组织缺损的患者非常常见。轻度创伤常导致轻度皮肤损伤，而严重损伤往往伴有骨骼和肌腱外露，给患者带来极大痛苦。对于皮肤和软组织缺损，传统治疗方法大多是中厚或全厚皮片或皮瓣移植。这些方法在伤口修复方面有效，但仍存在许多问题。近年来，随着组织工程技术的进步，使用人工皮肤修复各种皮肤伤口逐渐走向临床，而皮肤组织工程的关键技术在于真皮替代物的研发。人工真皮的出现不仅解决了自体皮肤来源短缺的问题，还使手术简单易行。本研究的目的是探讨人工真皮联合自体皮片移植修复手足皮肤软组织缺损伴骨外露的临床效果。结果表明，采用人工真皮联合自体刃厚皮治疗手足软组织损伤伴骨外露患者，临床效果良好，皮片成活且并发症少，值得推广。
