Ye Zenghui, Zhu Rongjin, Wang Feng, Jiang Haobin, Zhang Fengzhi
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.
Org Lett. 2021 Nov 5;23(21):8240-8245. doi: 10.1021/acs.orglett.1c02991. Epub 2021 Oct 26.
Atom- and step-economic oxo-azidation and oxo-hydroxyphthalimidation of styrenes have been developed under mild electrolytic conditions, respectively. Various valuable alpha-azido or hydroxyphthalimide aromatic ketones were synthesized efficiently from readily available styrenes, azides, and -hydroxyphthalimides. Mechanism studies show that two different pathways involved in these two transformations.
在温和的电解条件下，分别开发了苯乙烯的原子经济和步骤经济的氧代氧化反应以及氧代羟基邻苯二甲酰亚胺化反应。由易得的苯乙烯、叠氮化物和羟基邻苯二甲酰亚胺高效合成了各种有价值的α-叠氮基或羟基邻苯二甲酰亚胺芳香酮。机理研究表明，这两种转化涉及两种不同的途径。
