48538Zahedan University of Medical Sciences, Zahedan, Iran.
Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211051714. doi: 10.1177/10760296211051714.
Postpartum hemorrhage (PPH) is a major cause of maternal mortality, which is a common clinical manifestation in women with rare bleeding disorders. In this study, we compare PPH and its complications in heterozygote factor XIII (FXIII) deficient women with healthy women. In this cross sectional case study, 50 women with heterozygote FXIII deficiency and 50 healthy women are evaluated. Data were initially collected by interviewing the women who were receiving FXIII replacement therapy after their childbirths. Data were analysed using SPSS (Version 22) and a -value of less than .05 was considered statistically significant. The mean age in the patient and control groups were 31.2 and 32.5 years respectively. The occurring rate of PPH in the patient group was significantly higher than the control group (34% vs 2%) (-value <.0001). None of the confounding variables such as maternal age, gestational age, numbers, and types of delivery in women with PPH showed any significant differences between the control and patient groups. According to the results of this study, the risk of PPH (early and late), miscarriage, and menorrhagia in women who are heterozygous for FXIII deficiency is significantly higher than healthy women. However, the effect of other factors such as maternal age, gestational age, number, and type of delivery require further studies to delineate any confounding factors.
产后出血（PPH）是产妇死亡的主要原因，在罕见出血性疾病的女性中是一种常见的临床表现。在这项研究中，我们比较了杂合子因子 XIII（FXIII）缺乏症女性与健康女性的 PPH 及其并发症。在这项横断面病例研究中，评估了 50 名杂合子 FXIII 缺乏症女性和 50 名健康女性。数据最初通过对产后接受 FXIII 替代治疗的女性进行访谈收集。使用 SPSS（版本 22）进行数据分析，p 值小于 0.05 被认为具有统计学意义。患者组和对照组的平均年龄分别为 31.2 岁和 32.5 岁。患者组的 PPH 发生率明显高于对照组（34%对 2%）（p 值<.0001）。在患有 PPH 的女性中，母体年龄、胎龄、分娩次数和类型等混杂变量均无显著差异。根据这项研究的结果，FXIII 杂合子缺乏症女性发生 PPH（早期和晚期）、流产和月经过多的风险明显高于健康女性。然而，其他因素（如母体年龄、胎龄、分娩次数和类型）的影响需要进一步研究以阐明任何混杂因素。
