Department of Health Promotion and Development, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Hypertens Pregnancy. 2021 Nov;40(4):312-321. doi: 10.1080/10641955.2021.1987453. Epub 2021 Oct 26.
Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy. These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.
检查超重/肥胖个体中子痫前期（n=28 例）和正常血压（n=28 例）妊娠的白细胞（WBC）比例。WBC 比例是从全基因组 DNA 甲基化数据中推断出来的，并根据病例/对照状态和自我认定的种族进行比较。在第 1 孕期，整个样本中病例组的平均 B 细胞比例有降低的趋势，且白人参与者中比例显著降低，但黑人参与者中没有这种情况。与子痫前期妊娠相比，正常血压妊娠的 WBC 比例变化更为显著。在一个小样本中发现的这些结果表明，需要进一步研究自我认定的种族与妊娠期间白细胞之间的关系。
