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针对 SARS-CoV-2 及其变体的多样化疫苗平台。

Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants.

机构信息

Chemical Science, National Institute of Pharmaceutical Education and Research, Hyderabad, India.

Proteomics and Cell Signaling, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.

出版信息

Expert Rev Vaccines. 2022 Jan;21(1):47-67. doi: 10.1080/14760584.2022.1997601. Epub 2022 Jan 11.

Abstract

INTRODUCTION

Appearances of SARS-CoV-2 variants have created havoc and additional challenges for the ongoing vaccination drive against pandemic COVID-19. Interestingly, several vaccine platforms are showing great potential to produce successful vaccines against SARS-CoV-2 and its variants. Billions of COVID-19 vaccine doses have been administered worldwide. Mix-and-Match COVID-19 vaccines involving the mixing of the same platform vaccines and also two different vaccine platforms may provide greater protection against SARS-CoV-2 and its variants. COVID-19 vaccines have become one of the most important tools to mitigate the ongoing pandemic COVID-19.

AREAS COVERED

We describe SARS-Cov-2 variants, their impact on the population, COVID-19 vaccines, diverse vaccine platforms, doses of vaccines, the efficacy of vaccines against SARS-CoV-2 and its variants, mitigation of the COVID-19 transmission- alternatives to vaccines.

EXPERT OPINION

Diverse vaccine platforms may safeguard against ongoing, deadly SARS-CoV-2 and its infectious variants. The efficacies of COVID-19 vaccines are significantly high after the administration of the second dose. Further, it protects individuals including vulnerable patients with co-morbidities from SARS-CoV-2 and its variants. The hospitalizations and deaths of the individuals may be prevented by COVID-19 vaccines.

摘要

简介

SARS-CoV-2 变体的出现给正在进行的大流行 COVID-19 疫苗接种工作带来了严重破坏和额外挑战。有趣的是,几种疫苗平台显示出了针对 SARS-CoV-2 及其变体产生成功疫苗的巨大潜力。全世界已经接种了数十亿剂 COVID-19 疫苗。涉及同一平台疫苗混合以及两种不同疫苗平台混合的“混打” COVID-19 疫苗可能提供针对 SARS-CoV-2 及其变体的更大保护。COVID-19 疫苗已成为减轻大流行 COVID-19 的最重要工具之一。

涵盖领域

我们描述了 SARS-CoV-2 变体、它们对人群的影响、COVID-19 疫苗、不同的疫苗平台、疫苗剂量、疫苗对 SARS-CoV-2 及其变体的疗效、COVID-19 传播的缓解——疫苗替代品。

专家意见

不同的疫苗平台可能预防持续存在的、致命的 SARS-CoV-2 及其传染性变体。接种第二剂疫苗后,COVID-19 疫苗的功效显著提高。此外,它可以保护包括患有合并症的脆弱患者在内的个体免受 SARS-CoV-2 及其变体的侵害。COVID-19 疫苗可以预防个体的住院和死亡。

相似文献

1
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants.针对 SARS-CoV-2 及其变体的多样化疫苗平台。
Expert Rev Vaccines. 2022 Jan;21(1):47-67. doi: 10.1080/14760584.2022.1997601. Epub 2022 Jan 11.
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Vaccines against SARS-CoV-2 variants and future pandemics.针对 SARS-CoV-2 变体和未来大流行的疫苗。
Expert Rev Vaccines. 2022 Oct;21(10):1363-1376. doi: 10.1080/14760584.2022.2110075. Epub 2022 Aug 12.
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Expert review on global real-world vaccine effectiveness against SARS-CoV-2.全球真实世界 SARS-CoV-2 疫苗有效性的专家评价
Expert Rev Vaccines. 2022 Sep;21(9):1255-1268. doi: 10.1080/14760584.2022.2092472. Epub 2022 Jun 30.

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