Chemical Science, National Institute of Pharmaceutical Education and Research, Hyderabad, India.
Proteomics and Cell Signaling, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
Expert Rev Vaccines. 2022 Jan;21(1):47-67. doi: 10.1080/14760584.2022.1997601. Epub 2022 Jan 11.
Appearances of SARS-CoV-2 variants have created havoc and additional challenges for the ongoing vaccination drive against pandemic COVID-19. Interestingly, several vaccine platforms are showing great potential to produce successful vaccines against SARS-CoV-2 and its variants. Billions of COVID-19 vaccine doses have been administered worldwide. Mix-and-Match COVID-19 vaccines involving the mixing of the same platform vaccines and also two different vaccine platforms may provide greater protection against SARS-CoV-2 and its variants. COVID-19 vaccines have become one of the most important tools to mitigate the ongoing pandemic COVID-19.
We describe SARS-Cov-2 variants, their impact on the population, COVID-19 vaccines, diverse vaccine platforms, doses of vaccines, the efficacy of vaccines against SARS-CoV-2 and its variants, mitigation of the COVID-19 transmission- alternatives to vaccines.
Diverse vaccine platforms may safeguard against ongoing, deadly SARS-CoV-2 and its infectious variants. The efficacies of COVID-19 vaccines are significantly high after the administration of the second dose. Further, it protects individuals including vulnerable patients with co-morbidities from SARS-CoV-2 and its variants. The hospitalizations and deaths of the individuals may be prevented by COVID-19 vaccines.
SARS-CoV-2 变体的出现给正在进行的大流行 COVID-19 疫苗接种工作带来了严重破坏和额外挑战。有趣的是,几种疫苗平台显示出了针对 SARS-CoV-2 及其变体产生成功疫苗的巨大潜力。全世界已经接种了数十亿剂 COVID-19 疫苗。涉及同一平台疫苗混合以及两种不同疫苗平台混合的“混打” COVID-19 疫苗可能提供针对 SARS-CoV-2 及其变体的更大保护。COVID-19 疫苗已成为减轻大流行 COVID-19 的最重要工具之一。
我们描述了 SARS-CoV-2 变体、它们对人群的影响、COVID-19 疫苗、不同的疫苗平台、疫苗剂量、疫苗对 SARS-CoV-2 及其变体的疗效、COVID-19 传播的缓解——疫苗替代品。
不同的疫苗平台可能预防持续存在的、致命的 SARS-CoV-2 及其传染性变体。接种第二剂疫苗后,COVID-19 疫苗的功效显著提高。此外,它可以保护包括患有合并症的脆弱患者在内的个体免受 SARS-CoV-2 及其变体的侵害。COVID-19 疫苗可以预防个体的住院和死亡。