Seldenrijk C A, Verheggen W J, Veldhuizen R W, Blok A P, Ooms E C
Acta Cytol. 1987 Mar-Apr;31(2):137-42.
Because of the rise in incidence of upper urinary tract tumors, there is a need for a simple and reliable method for diagnosing these tumors, especially in people in a "high-risk" group. This retrospective study showed the usefulness of cytology and cytomorphometry in making the diagnosis of transitional-cell carcinoma of the upper urinary tract. The study also emphasized that the methods of collection and processing are of the utmost importance: the cytologic evaluation of ureteral catheterized urine specimens gave 100% accuracy as compared with a 40% false-negative rate in the cytologic diagnosis of voided urine specimens. A higher accuracy of urinary cytology for the diagnosis of upper urinary tract lesions clearly requires selective catheterization of the ureter. Objective cytomorphologic grading of the urinary cytology specimens was shown to compare favorably with histologic grading. Cytomorphologic grading not only can offer important information in determining the prognosis and in planning treatment but can also assist in quality control of other diagnostic methods and can help to resolve apparent diagnostic discrepancies.
由于上尿路肿瘤的发病率上升，需要一种简单可靠的方法来诊断这些肿瘤，尤其是在“高危”人群中。这项回顾性研究显示了细胞学和细胞形态计量学在上尿路移行细胞癌诊断中的有用性。该研究还强调，采集和处理方法至关重要：输尿管插管尿液标本的细胞学评估准确率为100%，而排尿尿液标本的细胞学诊断假阴性率为40%。显然，要提高尿液细胞学对上尿路病变诊断的准确性，就需要对输尿管进行选择性插管。尿液细胞学标本的客观细胞形态学分级显示与组织学分级相当。细胞形态学分级不仅可以在确定预后和制定治疗方案时提供重要信息，还可以协助其他诊断方法的质量控制，并有助于解决明显的诊断差异。
