Wang Dong-Bin, Li Xuan, Lu Xi-Ke, Sun Zhong-Yi, Zhang Xun, Chen Xia, Ma Lan, Xia Hong-Gang
Department of Thoracic Surgery, Tianjin Hospital, Tianjin, China.
Department of Graduate School, Tianjin Medical University, Tianjin, China.
Cancer Biother Radiopharm. 2021 Oct 25. doi: 10.1089/cbr.2021.0261.
Lung malignancy is a main source of disease passing all throughout the planet, whereas the transthyretin (TTR) is a specific biomarker for clinical diagnosis. However, its role in lung malignancy stays to be obscure. In the current examination, the authors made an endeavor to research impact of abnormal expression of TTR on nonsmall cell lung carcinoma (NSCLC) by overexpression or knockdown of TTR. To further explore the instruments' fundamental mechanism part of TTR in NSCLC, several signal pathways were searched and verified. To confirm the effect of TTR overexpression on tumors, experiments were conducted. It was found that upregulated TTR clearly stifled cell proliferation, migration, invasion, and expanded apoptosis. Significant suppression of phosphor-extracellular signal-regulated kinase (ERK) was observed in TTR-treated NSCLC cells, implying that TTR was important for cellular progress by regulating mitogen-activated protein kinase/ERK signaling pathway. In experiment, overexpression of TTR promoted cell apoptosis and inhibited tumor growth. Overall, the results suggest that TTR has a potential antitumor effect in human NSCLC progression, which provides theoretical basis for the diagnosis and treatment of NSCLC. Above all, further understanding of TTR was useful for clinical care. Clinical Trial Registration Number: 2016-08.
肺癌是全球疾病死亡的主要原因之一，而转甲状腺素蛋白（TTR）是临床诊断的一种特异性生物标志物。然而，其在肺癌中的作用仍不清楚。在当前的研究中，作者试图通过过表达或敲低TTR来研究TTR异常表达对非小细胞肺癌（NSCLC）的影响。为了进一步探究TTR在NSCLC中的作用机制，研究人员对几条信号通路进行了探索和验证。为了证实TTR过表达对肿瘤的影响，研究人员开展了实验。结果发现，上调TTR明显抑制细胞增殖、迁移、侵袭，并增加凋亡。在TTR处理的NSCLC细胞中观察到磷酸化细胞外信号调节激酶（ERK）受到显著抑制，这表明TTR通过调节丝裂原活化蛋白激酶/ERK信号通路对细胞进程具有重要作用。在实验中，TTR过表达促进细胞凋亡并抑制肿瘤生长。总体而言，结果表明TTR在人类NSCLC进展中具有潜在的抗肿瘤作用，这为NSCLC的诊断和治疗提供了理论依据。最重要的是，进一步了解TTR对临床治疗很有帮助。临床试验注册号：2016 - 08。
