Department of Hepato-Biliary-Pancreatic Surgery, The Affiliated Ningbo Medical Center of LiHuiLi Hospital of Medical School of Ningbo University, Ningbo, 315048, China.
The Affiliated Hospital of Medical School, Ningbo University, Ningbo, 315020, China.
Mol Biol Rep. 2022 Jan;49(1):735-746. doi: 10.1007/s11033-021-06869-x. Epub 2021 Oct 26.
Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomerulosclerosis and cancers, such as colorectal and thyroid cancer where it functions as a tumor suppressor, glioblastoma, breast, prostate, and gastric cancer, via its oncogenic function. However, studies on the underlying molecular mechanisms of the different roles of INF2 in diverse cancers are limited. This review comprehensively describes the structure, biochemical features, and primary pathogenic mutations of INF2.
formin 蛋白可催化肌动蛋白成核和微丝聚合。反向formin2（INF2）是一种非典型的丝切蛋白相关formin，其特征在于肌动蛋白的聚合和去聚合。越来越多的证据表明，INF2 与肾脏疾病局灶节段性肾小球硬化症和癌症有关，如结直肠癌和甲状腺癌，在这些癌症中，它作为肿瘤抑制因子发挥作用，而在神经胶质瘤、乳腺癌、前列腺癌和胃癌中，它通过其致癌功能发挥作用。然而，关于 INF2 在不同癌症中不同作用的潜在分子机制的研究还很有限。本综述全面描述了 INF2 的结构、生化特征和主要致病突变。
