Postdoctoral Research Station of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, China; Department of Neurosurgery, Affiliated Hospital of Hebei University, Hebei University, China; Key Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Affiliated Hospital of Hebei University, Hebei University, China.
Department of Neurology, Affiliated Hospital of Hebei University, Hebei University, China.
Neurosci Res. 2022 Mar;176:9-17. doi: 10.1016/j.neures.2021.10.008. Epub 2021 Oct 23.
Following spinal cord injury (SCI), the central nervous system undergoes significant reconstruction. The dynamic change in the interaction of the brain-spinal cord axis as well as in structure-function relations plays a vital role in the determination of neurological functions, which might have important clinical implications for the treatment and its efficacy evaluation of patients with SCI. Brain connectomes based on neuroimaging data is a relatively new field of research that maps the brain's large-scale structural and functional networks at rest. Importantly, increasing evidence shows that such resting-state signals can also be seen in the spinal cord. In the present review, we focus on the reconstruction of multi-level neural circuits after SCI. We also describe how the connectome concept could further our understanding of neuroplasticity after SCI. We propose that mapping the cortical-subcortical-spinal cord networks can provide novel insights into the pathologies of SCI.
脊髓损伤（SCI）后，中枢神经系统会发生显著的重建。大脑-脊髓轴相互作用以及结构-功能关系的动态变化在神经功能的确定中起着至关重要的作用，这可能对 SCI 患者的治疗及其疗效评估具有重要的临床意义。基于神经影像学数据的脑连接组学是一个相对较新的研究领域，它可以绘制大脑在静息状态下的大规模结构和功能网络。重要的是，越来越多的证据表明，这种静息状态信号也可以在脊髓中看到。在本综述中，我们重点关注 SCI 后多水平神经回路的重建。我们还描述了连接组学概念如何进一步帮助我们理解 SCI 后的神经可塑性。我们提出，绘制皮质-皮质下-脊髓网络图谱可以为 SCI 的病理学提供新的见解。
