Coulm B
DMU ESPRIT (épidémiologie et biostatistique, santé publique, pharmacie, pharmacologie, recherche, information médicale, thérapeutique et médicaments), centre de référence sur les agents tératogènes (CRAT), GHU, Sorbonne université, AP-HP, site Trousseau, 26, avenue Docteur-Netter, 75571 Paris cedex 12, France.
Gynecol Obstet Fertil Senol. 2021 Dec;49(12):947-950. doi: 10.1016/j.gofs.2021.10.009. Epub 2021 Oct 23.
Although there is no recommendation in France relating to the treatment of nausea and vomiting of pregnancy, there are some in other countries, where ondansetron, widely used, appears to be an effective second-line treatment option behind doxylamine/vitamin B6 association and metoclopramide. However, based on some recent publication suggesting an increased risk of orofacial clefts and congenital heart defects in fetuses exposed in utero to ondansetron in the 1st trimester of pregnancy, the European Medicines Agency now states that this drug should not longer be used during this period. This 2019 decision is controversial and whether ondansetron can be used in pregnant women with severe vomiting during pregnancy is still in question.
虽然法国没有关于治疗妊娠恶心和呕吐的建议，但其他国家有一些相关建议，在这些国家，广泛使用的昂丹司琼似乎是仅次于多西拉敏/维生素B6联合用药和甲氧氯普胺的有效二线治疗选择。然而，基于最近一些出版物表明，在妊娠头三个月子宫内接触昂丹司琼的胎儿出现口面部裂和先天性心脏缺陷的风险增加，欧洲药品管理局现在指出，在此期间不应再使用这种药物。这一2019年的决定存在争议，妊娠期间严重呕吐的孕妇是否可以使用昂丹司琼仍存在疑问。
