涎腺分泌性癌——小儿病例报告及病例系列的系统评价
Secretory carcinoma of salivary gland - A systematic review of pediatric case reports and case series.
作者信息
Vasanthi V, Ramadoss R
机构信息
Lecturer, Department of Oral Pathology and Microbiology, SRM Dental College, Chennai, Tamil Nadu, India.
Professor, Department of Oral Pathology and Microbiology, Saveetha Dental College, Chennai, Tamil Nadu, India.
出版信息
J Oral Maxillofac Pathol. 2021 May-Aug;25(2):327-331. doi: 10.4103/0973-029X.325236. Epub 2021 Aug 31.
AIM
Mammary analog secretory carcinoma (MASC) is a new pathological entity of salivary gland origin recognized as Secretory Carcinoma (SC) in the WHO 2017 classification. Pediatric cases of MASC were reviewed systematically from 2010 to 2019.
MATERIALS AND METHODS
Databases were searched from 2010 to 2019 for pediatric case reports and case series, excluding retrospective studies. A total of 12 manuscripts were reviewed for clinical, histological and immunohistochemical findings.
RESULTS
A total of 13 pediatric cases (11 case reports and 1 case series of 2 cases) of MASC in pediatric patients were found. The youngest reported age was 5 years. The common site was parotid gland usually presenting as a slowly growing firm, painless mass.
CONCLUSION
MASC should be considered in the differential diagnosis of salivary gland tumors in pediatric population, especially from parotid gland. Extended research on such recent entities with more inputs from new cases reported in literature may outstretch the possibilities of therapeutic fusion inhibition in future.
目的
乳腺样分泌性癌（MASC）是一种起源于唾液腺的新病理实体，在世界卫生组织2017年分类中被认定为分泌性癌（SC）。对2010年至2019年期间的儿童MASC病例进行了系统回顾。
材料与方法
检索2010年至2019年的数据库，查找儿童病例报告和病例系列，排除回顾性研究。共审查了12篇关于临床、组织学和免疫组化结果的手稿。
结果
共发现13例儿童患者的MASC病例（11例病例报告和1例包含2例的病例系列）。报告的最年轻年龄为5岁。常见部位是腮腺，通常表现为生长缓慢的坚实、无痛肿块。
结论
在儿童唾液腺肿瘤的鉴别诊断中应考虑MASC，尤其是来自腮腺的肿瘤。对这类新出现的实体进行更多文献报道的新病例投入的深入研究，可能会拓展未来治疗性融合抑制的可能性。
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