中药综合疗法治疗慢性盆腔疼痛的回顾性研究：179例（2016 - 2018年）
A Retrospective Study on Chronic Pelvic Pain Treated with Traditional Chinese Medicine Combined Therapy: 179 Cases (2016-2018).
作者信息
Guo Shanshan, Chen Yijia, Tang Qianjue, Liu Lian, Xu Lianwei
机构信息
Gynecology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
出版信息
J Pain Res. 2021 Oct 14;14:3239-3250. doi: 10.2147/JPR.S329317. eCollection 2021.
PURPOSE
This study aims to evaluate clinical efficiency and side effects of combined therapy of traditional Chinese medicine in female treating chronic pelvic pain.
METHODS
A retrospective study was conducted by analyzing 179 patients with chronic pelvic pain. They were divided into the 3-course group and the 1-course group. Patients in the 3-course group received combined therapy of traditional Chinese medicine 10 days per menstrual cycle for three months, while the 1-course group received the same combined therapy for only one menstrual cycle. VAS scores of five kinds of pain were compared between the two groups. Meanwhile, SF-36 scores, menstruation, leucorrhea and major accompanying symptoms were analyzed. To assess side effects of the combined therapy, safety indices were recorded before and after treatment as well.
RESULTS
VAS scores of patients in the 3-course group after treatment were significantly lower than that before the treatment. Total scores of SF-36 were significantly improved after the treatment, and persistently improved even after the discontinuation of the treatment. The menstrual and leucorrhea condition improved as well after the treatment. In addition, among the concomitant symptoms, insomnia, loss of appetite, mental fatigue symptoms were significantly improved after the treatment. More importantly, significances were observed in the improvement of most VAS scores between patients who underwent a 1-course treatment and patients with a 3-course treatment. Meanwhile, no significant change was observed in safety indices before and after treatment. Possible adverse events related to the treatment plan for all enrolled patients included mild skin rash in 16 patients, stomachache in 3 patients after taking medicine on an empty stomach, and oral ulcer in 1 patient.
CONCLUSION
Combined therapy of traditional Chinese medicine alleviated symptoms of chronic pelvic pain, soothed the accompanying symptoms, and hence helped to improve the life quality of women.
目的
本研究旨在评估中药联合疗法治疗女性慢性盆腔疼痛的临床疗效及副作用。
方法
通过分析179例慢性盆腔疼痛患者进行回顾性研究。将患者分为3疗程组和1疗程组。3疗程组患者在每个月经周期接受10天的中药联合治疗，持续三个月，而1疗程组仅在一个月经周期接受相同的联合治疗。比较两组五种疼痛的视觉模拟评分（VAS）。同时，分析健康调查简表36（SF-36）评分、月经、白带及主要伴随症状。为评估联合治疗的副作用，还记录了治疗前后的安全指标。
结果
3疗程组患者治疗后的VAS评分显著低于治疗前。治疗后SF-36总分显著改善，甚至在停药后仍持续改善。治疗后月经和白带状况也有所改善。此外，在伴随症状中，失眠、食欲不振、精神疲劳症状在治疗后显著改善。更重要的是，1疗程治疗患者和3疗程治疗患者之间，大多数VAS评分的改善存在显著差异。同时，治疗前后安全指标未观察到显著变化。所有纳入患者与治疗方案相关的可能不良事件包括16例轻度皮疹、3例空腹服药后胃痛、1例口腔溃疡。
结论
中药联合疗法缓解了慢性盆腔疼痛症状，舒缓了伴随症状，从而有助于提高女性的生活质量。
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