Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Arq Neuropsiquiatr. 2021 Oct;79(10):871-878. doi: 10.1590/0004-282X-ANP-2020-0549.
The cuneiform nucleus is located in the center of the circuit that mediates autonomic responses to stress. Hemorrhagic hypotension leads to chemoreceptor anoxia, which consequently results in the reduction of baroreceptor discharge and stimulation of the chemoreceptor.
Using the single-unit recording technique, the neuronal activities of the cuneiform nucleus were investigated in hypotensive states induced by hemorrhage and administration of an anti-hypertensive drug (hydralazine).
Thirty male rats were divided into the control, hemorrhage, and hydralazine groups. The femoral artery was cannulated for the recording of cardiovascular responses, including systolic blood pressure, mean arterial pressure, and heart rate. Hydralazine was administered via tail vein. The single-unit recording was performed from the cuneiform nucleus.
The maximal systolic blood pressure and the mean arterial pressure significantly decreased and heart rate significantly increased after the application of hydralazine as well as the following hemorrhage compared to the control group. Hypotension significantly increased the firing rate of the cuneiform nucleus in both the hemorrhage and hydralazine groups compared to the control group.
The present data indicate that the cuneiform nucleus activities following hypotension may play a crucial role in blood vessels and vasomotor tone.
楔状核位于介导应激自主反应的回路中心。出血性低血压导致化学感受器缺氧，从而导致压力感受器放电减少和化学感受器刺激。
使用单单位记录技术，研究了由出血和抗高血压药物（肼屈嗪）引起的低血压状态下楔状核的神经元活动。
将 30 只雄性大鼠分为对照组、出血组和肼屈嗪组。股动脉插管用于记录心血管反应，包括收缩压、平均动脉压和心率。通过尾静脉给予肼屈嗪。从楔状核进行单单位记录。
与对照组相比，应用肼屈嗪以及随后的出血后，最大收缩压和平均动脉压显著降低，心率显著增加。与对照组相比，低血压显著增加了出血组和肼屈嗪组楔状核的放电率。
目前的数据表明，低血压后楔状核的活动可能在血管和血管张力中起关键作用。
