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The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells.

作者信息

Rodriguez-Cortez Virginia C, Navarrete-Meneses Maria Pilar, Molina Oscar, Velasco-Hernandez Talia, Gonzalez Jessica, Romecin Paola, Gutierrez-Aguera Francisco, Roca-Ho Heleia, Vinyoles Meritxell, Kowarz Eric, Marin Pedro, Rodriguez-Perales Sandra, Gomez-Marin Carlos, Perez-Vera Patricia, Cortes-Ledesma Felipe, Bigas Anna, Terron Andrea, Bueno Clara, Menendez Pablo

机构信息

Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona.

Laboratorio de Genetica y Cancer, Departamento de Genetica Humana, Instituto Nacional de Pediatria, Ciudad de Mexico.

出版信息

Haematologica. 2022 Feb 1;107(2):544-549. doi: 10.3324/haematol.2021.279047.

DOI:10.3324/haematol.2021.279047
PMID:34706497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8804580/
Abstract
摘要

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Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.

本文引用的文献

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Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence.拟除虫菊酯类农药暴露与血液系统癌症：流行病学、生物学和分子证据。
Rev Environ Health. 2019 Jun 26;34(2):197-210. doi: 10.1515/reveh-2018-0070.
2
Low concentrations of permethrin and malathion induce numerical and structural abnormalities in KMT2A and IGH genes in vitro.低浓度的氯菊酯和马拉硫磷在体外诱导 KMT2A 和 IGH 基因的数量和结构异常。
J Appl Toxicol. 2018 Sep;38(9):1262-1270. doi: 10.1002/jat.3638. Epub 2018 May 9.
3
ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
ZATT（ZNF451）介导的拓扑异构酶2 DNA-蛋白质交联的解离。
Science. 2017 Sep 29;357(6358):1412-1416. doi: 10.1126/science.aam6468. Epub 2017 Sep 14.
4
Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.胎儿肝脏造血细胞中DNA损伤反应失调与KMT2A重排
PLoS One. 2015 Dec 11;10(12):e0144540. doi: 10.1371/journal.pone.0144540. eCollection 2015.
5
Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells.毒死蜱通过半胱天冬酶3依赖性基因组不稳定和拓扑异构酶II抑制作用在人胎儿肝脏造血干细胞中诱导混合谱系白血病基因易位。
Toxicol Sci. 2015 Oct;147(2):588-606. doi: 10.1093/toxsci/kfv153. Epub 2015 Jul 20.
6
Pyrethroid pesticide exposure and risk of childhood acute lymphocytic leukemia in Shanghai.拟除虫菊酯类农药暴露与上海儿童急性淋巴细胞白血病风险
Environ Sci Technol. 2012 Dec 18;46(24):13480-7. doi: 10.1021/es303362a. Epub 2012 Nov 29.
7
In utero pesticide exposure and leukemia in Brazilian children < 2 years of age.子宫内杀虫剂暴露与巴西 2 岁以下儿童白血病。
Environ Health Perspect. 2013 Feb;121(2):269-75. doi: 10.1289/ehp.1103942. Epub 2012 Oct 22.
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Residential pesticides and childhood leukemia: a systematic review and meta-analysis.住宅用农药与儿童白血病：系统评价与荟萃分析。
Environ Health Perspect. 2010 Jan;118(1):33-41. doi: 10.1289/ehp.0900966.
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