García Muro Andrea Marlene, García Ruvalcaba Azaria, Rizo de la Torre Lourdes Del Carmen, Sánchez López Josefina Yoaly
División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, México.
Doctorado en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
Growth Factors. 2021 Feb-Jul;39(1-6):1-13. doi: 10.1080/08977194.2021.1994964. Epub 2021 Oct 28.
The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-β) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells. BMP6 is coded by a tumor suppressor gene whose subexpression is related to the development and cancer progression; during neoplastic processes, methylation is the main mechanism by which gene silencing occurs. This work presents a review on the role of BMP6 protein in breast cancer (BC) and other types of cancer. The studies carried out to date suggest the participation of the BMP6 protein in the epithelial-mesenchymal transition (EMT) phenotype, cell growth and proliferation; however, these processes are affected in a variable way in the different types of cancer, the methylated CpG sites in gene promoter, as well as the interaction with other proteins could be the cause of such variation.
骨形态发生蛋白6（BMP6）是转化生长因子-β（TGF-β）配体超家族的一部分，参与铁稳态，通过增加黏附力和细胞间相互作用抑制侵袭，并直接诱导血管内皮细胞的血管生成。BMP6由一个肿瘤抑制基因编码，其表达下调与肿瘤发生发展及癌症进展相关；在肿瘤形成过程中，甲基化是导致基因沉默的主要机制。本文综述了BMP6蛋白在乳腺癌（BC）及其他类型癌症中的作用。迄今为止的研究表明，BMP6蛋白参与上皮-间质转化（EMT）表型、细胞生长和增殖；然而，这些过程在不同类型的癌症中受到不同程度的影响，基因启动子中的甲基化CpG位点以及与其他蛋白质的相互作用可能是造成这种差异的原因。
