Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
BMC Psychiatry. 2021 Oct 27;21(1):531. doi: 10.1186/s12888-021-03548-w.
This study aims to explore the difference in anhedonia between Major Depressive Disorder (MDD) and Bipolar Disorder II (BD-II), and attempt to distinguish the two diseases through Snaith-Hamilton Pleasure Scale (SHAPS).
A total of 164 drug-free depressive patients (98 MDD patients, 66 BD-II patients) completed the investigation. 17-item Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA) and SHAPS were assessed in all participants.
Our results showed that BD-II patients had higher SHAPS scores than MDD patients. The stepwise logistic regression analysis further revealed that SHAPS score, drinking habit, and extroversion as influencing factors for the identification of BD-II. The ROC curve analysis indicated that SHAPS could differentiate BD-II from MDD patients (AUC = 0.655, P = 0.001, 95% CI = 0.568 to 0.742), with the best screening cutoff at 26, and the corresponding sensitivity and specificity was 0.788 and 0.520, respectively.
Our results suggest that BD-II patients had more severe anhedonia compared to MDD patients, and the difference in anhedonia may help clinicians preliminary identify BD patients from MDD patients. The preliminary findings are worthly of further exploration.
本研究旨在探讨重性抑郁障碍（MDD）与双相情感障碍 II 型（BD-II）之间快感缺失的差异，并尝试通过 Snaith-Hamilton 快感量表（SHAPS）来区分这两种疾病。
共纳入 164 名未用药的抑郁患者（98 名 MDD 患者，66 名 BD-II 患者）参与本研究。所有参与者均完成了 17 项汉密尔顿抑郁量表（HAMD-17）、汉密尔顿焦虑量表（HAMA）和 SHAPS 的评估。
我们的研究结果表明，BD-II 患者的 SHAPS 评分高于 MDD 患者。逐步逻辑回归分析进一步表明，SHAPS 评分、饮酒习惯和外向性是区分 BD-II 的影响因素。ROC 曲线分析表明，SHAPS 可以区分 BD-II 与 MDD 患者（AUC=0.655，P=0.001，95%CI=0.568 至 0.742），最佳筛查截断值为 26，对应的灵敏度和特异性分别为 0.788 和 0.520。
我们的研究结果表明，BD-II 患者的快感缺失比 MDD 患者更严重，快感缺失的差异可能有助于临床医生初步从 MDD 患者中识别 BD 患者。初步发现值得进一步探索。
