Stead R J, Barradas M A, Mikhailidis D P, Jeremy J Y, Hodson M E, Batten J C, Dandona P
Prostaglandins Leukot Med. 1987 Feb;26(2):91-103. doi: 10.1016/0262-1746(87)90104-1.
Platelet function was investigated in 15 patients with cystic fibrosis (CF) and in ten age-matched controls. Marked hyperaggregability of platelets to adrenaline, collagen and arachidonic acid was observed in platelet rich plasma (PRP) prepared from patients with cystic fibrosis. Thromboxane A2 (TXA2) release from these platelets was also markedly enhanced. Hyperaggregability and increased TXA2 release observed in patients with CF was not due to the higher platelet counts in these patients since hyperaggregability was observed even in those patients whose platelet counts were similar to those in controls. Platelet hyperaggregability and increased thromboxane release in these patients were also independent of their body weight and occurred despite supplementation with vitamin E. Hyperaggregability of platelets in CF may be clinically relevant since it may contribute to the pathogenesis of bronchoconstriction through the release of TXA2 and other bronchoconstrictor platelet products such as serotonin.
对15名囊性纤维化（CF）患者和10名年龄匹配的对照者的血小板功能进行了研究。在从囊性纤维化患者制备的富血小板血浆（PRP）中观察到血小板对肾上腺素、胶原蛋白和花生四烯酸的显著高聚集性。这些血小板的血栓素A2（TXA2）释放也显著增强。CF患者中观察到的高聚集性和TXA2释放增加并非由于这些患者血小板计数较高，因为即使在血小板计数与对照组相似的患者中也观察到了高聚集性。这些患者的血小板高聚集性和血栓素释放增加也与他们的体重无关，并且尽管补充了维生素E仍会发生。CF患者血小板的高聚集性可能具有临床相关性，因为它可能通过释放TXA2和其他支气管收缩性血小板产物（如血清素）导致支气管收缩的发病机制。
