Mikhailidis D P, Barradas M A, De Souza V, Jeremy J Y, Wakeling A, Dandona P
Prostaglandins Leukot Med. 1986 Sep;24(1):27-34. doi: 10.1016/0262-1746(86)90203-9.
Platelet aggregation and thromboxane A2 release in response to adrenaline and the relationship of this response to body weight was investigated in female patients with anorexia nervosa. Platelets obtained from patients with body weights below 75% of the expected average weight (Group I) showed significantly greater aggregation and TXA2 release in response to adrenaline when compared with controls matched for sex and age. Patients with body weights 75-95% of the expected average weight (Group II) did not show enhancement of platelet aggregation or TXA2 release. In Group I patients, platelet hyperaggregability and enhanced TXA2 release induced by adrenaline tended to normalise following inpatient treatment and weight gain: with 0.5 mumol/l adrenaline, the pre-weight gain median aggregation was 65%, whereas the post-weight gain value was 37% - P less than 0.01. Markedly underweight patients also had hyperaggregability following stimulation with ADP and collagen. This hyperaggregability also tended to normalise after weight gain but these changes were not statistically significant. Platelet hyperaggregability (especially in response to adrenaline) in anorexia nervosa is therefore secondary to weight loss and reverts to normal with normalisation of weight. These changes may reflect the previously documented increase in platelet alpha-adrenoceptors in thin patients with anorexia nervosa and their normalisation following weight gain. However, the hyperaggregability in response to agonists other than adrenaline suggests that an additional post-receptor mechanism may be involved.
对神经性厌食症女性患者进行了研究，以探讨血小板对肾上腺素的聚集反应和血栓素A2释放情况，以及这种反应与体重的关系。与年龄和性别匹配的对照组相比，体重低于预期平均体重75%的患者（第一组）的血小板对肾上腺素的聚集和血栓素A2释放明显更强。体重为预期平均体重75%-95%的患者（第二组）未表现出血小板聚集或血栓素A2释放增强。在第一组患者中，住院治疗和体重增加后，肾上腺素诱导的血小板高聚集性和血栓素A2释放增强趋于正常化：使用0.5μmol/l肾上腺素时，体重增加前的中位聚集率为65%，而体重增加后的数值为37%，P<0.01。明显体重过轻的患者在用ADP和胶原蛋白刺激后也有高聚集性。体重增加后这种高聚集性也趋于正常化，但这些变化无统计学意义。因此，神经性厌食症患者的血小板高聚集性（尤其是对肾上腺素的反应）继发于体重减轻，体重正常化后恢复正常。这些变化可能反映了先前记录的神经性厌食症消瘦患者血小板α-肾上腺素能受体增加以及体重增加后受体正常化。然而，对肾上腺素以外的激动剂的高聚集性表明可能涉及额外的受体后机制。
