Jing Xian-Dan, Tang Qin, He Jin-Han
Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital, Sichuan University, Chengdu 610041, China.
Sheng Li Xue Bao. 2021 Oct 25;73(5):745-754.
SIRT6, a member of the silencing information regulatory protein family, is a nicotinamide adenine dinucleotide-dependent histone deacetylase and an ADP-ribose transferase enzyme. It plays an important role in fundamental physiological and pathological processes, including lipid metabolism, inflammation, oxidative stress and fibrosis, and is considered as a potential therapeutic target for metabolic syndrome. SIRT6 knockout mice displayed severe fatty liver, and the expression of SIRT6 in the liver of nonalcoholic steatohepatitis (NASH) mice was significantly lower than that of normal mice. Overexpression of SIRT6 significantly ameliorated NASH-induced liver damage. It is suggested that SIRT6 may play a key role in protecting against NASH. In this paper, we review the important regulatory functions of SIRT6 in the occurrence and development of NASH.
沉默信息调节蛋白6（SIRT6）是沉默信息调节蛋白家族的成员之一，是一种烟酰胺腺嘌呤二核苷酸依赖性组蛋白脱乙酰酶和一种ADP核糖转移酶。它在包括脂质代谢、炎症、氧化应激和纤维化在内的基本生理和病理过程中发挥重要作用，被认为是代谢综合征的潜在治疗靶点。SIRT6基因敲除小鼠表现出严重的脂肪肝，非酒精性脂肪性肝炎（NASH）小鼠肝脏中SIRT6的表达明显低于正常小鼠。SIRT6的过表达显著改善了NASH诱导的肝损伤。提示SIRT6可能在预防NASH中起关键作用。在本文中，我们综述了SIRT6在NASH发生发展中的重要调节功能。
