Philips Consumer Lifestyle B.V., Drachten, The Netherlands.
School of Health Sciences, University of Southampton, Southampton, UK.
Skin Res Technol. 2022 Jan;28(1):187-199. doi: 10.1111/srt.13104. Epub 2021 Oct 27.
Skin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps and cosmetics), and mechanical forces (e.g., while shaving). From both industry and academia, many efforts have been taken to quantify the characteristics of SS in a standardised manner, but the study is hindered by the lack of an objective definition.
A review of the scientific literature regarding different parameters attributed to the loss of skin integrity and linked with exhibition of SS was conducted. Articles included were screened for mechanical stimulation of the skin, with objective quantification of tissue responses using biophysical or imaging techniques. Additionally, studies where cohorts of SS and non-SS individuals were reported have been critiqued.
The findings identified that the structure and function of the stratum corneum and its effective barrier properties are closely associated with SS. Thus, an array of skin tissue responses has been selected for characterization of SS due to mechanical stimuli, including: transepidermal water loss, hydration, redness, temperature, and sebum index. Additionally, certain imaging tools allow quantification of the superficial skin layers, providing structural characteristics underlying SS.
This review proposes a multimodal approach for identification of SS, providing a means to characterise skin tissue responses objectively. Optical coherence tomography (OCT) has been suggested as a suitable tool for dermatological research with clinical applications. Such an approach would enhance the knowledge underlying the multifactorial nature of SS and aid the development of personalised solutions in medical and consumer devices.
皮肤敏感（SS）是一种常见的对各种刺激的反应，包括环境条件（例如，阳光照射）、化学刺激物（例如，肥皂和化妆品）和机械力（例如，剃须时）。工业界和学术界都做出了许多努力，试图以标准化的方式量化 SS 的特征，但由于缺乏客观的定义，研究受到了阻碍。
对与皮肤完整性丧失相关并与 SS 表现相关的不同参数的科学文献进行了回顾。筛选出的文章均对皮肤进行了机械刺激，使用生物物理或成像技术对组织反应进行了客观量化。此外，还对报道了 SS 和非 SS 个体队列的研究进行了评估。
研究结果表明，角质层的结构和功能及其有效的屏障特性与 SS 密切相关。因此，由于机械刺激，选择了一系列皮肤组织反应来表征 SS，包括：经表皮水分流失、水合作用、发红、温度和皮脂指数。此外，某些成像工具允许量化浅层皮肤层，提供 SS 潜在的结构特征。
本综述提出了一种用于识别 SS 的多模态方法，提供了一种客观表征皮肤组织反应的方法。光相干断层扫描（OCT）已被建议作为具有临床应用的皮肤科研究的合适工具。这种方法将增强对 SS 多因素性质的认识，并有助于开发医疗和消费设备中的个性化解决方案。
