Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Gen Thorac Cardiovasc Surg. 2022 Jan;70(1):96-99. doi: 10.1007/s11748-021-01721-2. Epub 2021 Oct 28.
A 71-year-old female with type B3 thymoma developed severe aplastic anemia. Anti-thymocyte globulin was administered with glucocorticoids and cyclosporin A as the treatment for aplastic anemia. Computed tomography scan revealed that thymoma apparently shrank and remained without regrowth for at least 7 months. As previously reported, glucocorticoid has therapeutic effects on thymoma especially with abundant lymphocytes. Anti-thymocyte globulin also depletes peripheral lymphocytes, but its efficacy in the treatment of thymoma is unknown. Anti-thymocyte globulin and glucocorticoids may have cooperated with each other in reducing thymoma in our case. More cases should be accumulated to elucidate the effects of anti-thymocyte globulin on thymoma.
一位 71 岁女性，B3 型胸腺瘤患者，发生严重再生障碍性贫血。再生障碍性贫血治疗给予抗胸腺细胞球蛋白联合糖皮质激素和环孢素 A。胸部 CT 显示胸腺瘤明显缩小，至少 7 个月无复发。如前所述，糖皮质激素对富含淋巴细胞的胸腺瘤具有治疗作用。抗胸腺细胞球蛋白也会耗竭外周血淋巴细胞，但对胸腺瘤的疗效尚不清楚。在我们的病例中，抗胸腺细胞球蛋白和糖皮质激素可能相互协作，共同减少胸腺瘤。需要积累更多病例来阐明抗胸腺细胞球蛋白对胸腺瘤的作用。
