Department of Clinical Hematology, Qingdao University School of Medicine, Qingdao, China.
Int J Lab Hematol. 2022 Feb;44(1):74-81. doi: 10.1111/ijlh.13736. Epub 2021 Oct 28.
Human is the host of the Epstein-Barr virus (EBV) especially in childhood and adolescence. Most of them are asymptomatic infection and self-limiting. However, for those patients who suffer from immune dysfunction, EBV infection will be life-threatening. Epstein-Barr virus-associated hemophagocytic lymphohistocytosis (EBV-HLH) is one of the severe effects. The diagnosis and differential diagnosis of EBV-HLH and other EBV infectious diseases are mentioned in this paper. The molecular biology mechanism and complications of EBV-HLH are equally briefly presented. It also provides a practical method for the genetic diagnosis of such diseases and the differential diagnosis with other human immunodeficiency diseases for medical scientists in routine clinical practice.
人类是 Epstein-Barr 病毒（EBV）的宿主，尤其是在儿童和青少年时期。大多数人无症状感染并具有自限性。然而，对于那些患有免疫功能障碍的患者来说，EBV 感染可能会危及生命。EBV 相关噬血细胞性淋巴组织细胞增生症（EBV-HLH）就是其中一种严重的后果。本文提到了 EBV-HLH 与其他 EBV 感染性疾病的诊断和鉴别诊断。同样简要介绍了 EBV-HLH 的分子生物学机制和并发症。它还为常规临床实践中此类疾病的基因诊断和与其他人类免疫缺陷疾病的鉴别诊断提供了一种实用方法。
