Centro Nacional de Biotecnología, CSIC, 28049, Madrid, Spain.
Centro Nacional de Biotecnología, CSIC, 28049, Madrid, Spain.
Curr Opin Microbiol. 2021 Dec;64:125-132. doi: 10.1016/j.mib.2021.09.010. Epub 2021 Oct 26.
Pseudomonas aeruginosa, a bacterium characterized for its low antibiotics' susceptibility, is one of the most relevant opportunistic pathogens, causing infections at hospitals and in cystic fibrosis patients. Besides its relevance for human health, P. aeruginosa colonizes environmental ecosystems; therefore the elements driving its infectivity and antibiotic resistance must be analyzed from a One-Health perspective. Although some epidemic clones have been described, there are not specific lineages linked to infections, suggesting that P. aeruginosa virulence and antibiotic resistance determinants evolved in nature to play functions other than infecting the human host and avoiding antimicrobial treatment. Herein, we review current information on the population structure of P. aeruginosa and on the functional role that its resistance and virulence determinants have in non-clinical ecosystems.
铜绿假单胞菌是一种对抗生素敏感性较低的细菌，是最重要的机会性病原体之一，可引起医院和囊性纤维化患者的感染。除了对人类健康的重要性外，铜绿假单胞菌还定殖于环境生态系统中；因此，必须从一个健康的角度来分析导致其传染性和抗生素耐药性的因素。尽管已经描述了一些流行克隆，但与感染相关的特定谱系并不存在，这表明铜绿假单胞菌的毒力和抗生素耐药性决定因素是在自然界中进化而来的，其作用不是感染人类宿主和避免抗菌治疗，而是发挥其他功能。在此，我们综述了铜绿假单胞菌的种群结构以及其耐药性和毒力决定因素在非临床生态系统中所具有的功能作用的最新信息。
